NDUFV3

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial is an enzyme that in humans is encoded by the NDUFV3 gene.

NDUFV3
Identifiers
Aliases	NDUFV3, CI-10k, CI-9KD, NADH:ubiquinone oxidoreductase subunit V3
External IDs	OMIM: 602184 MGI: 1890894 HomoloGene: 10885 GeneCards: NDUFV3
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.3 Start 42,879,644 bp End 42,913,304 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 31,739,089 bp End 31,750,305 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle tibialis anterior muscle vastus lateralis muscle biceps brachii deltoid muscle body of tongue parotid gland vena cava gastrocnemius muscle corpus epididymis Top expressed in right ventricle digastric muscle aortic valve sternocleidomastoid muscle ascending aorta internal carotid artery triceps brachii muscle epithelium of stomach yolk sac temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function NADH dehydrogenase (ubiquinone) activity RNA binding protein binding Cellular component mitochondrial inner membrane respirasome membrane mitochondrion nucleoplasm mitochondrial respiratory chain complex I Biological process mitochondrial electron transport, NADH to ubiquinone mitochondrial respiratory chain complex I assembly mitochondrial ATP synthesis coupled electron transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4731 78330 Ensembl ENSG00000160194 ENSMUSG00000024038 UniProt P56181 Q8BK30 RefSeq (mRNA) NM_001001503 NM_021075 NM_001083891 NM_030087 RefSeq (protein) NP_001001503 NP_066553 NP_001077360 NP_084363 Location (UCSC) Chr 21: 42.88 – 42.91 Mb Chr 17: 31.74 – 31.75 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Sled VD, Vinogradov AD (1993). "Kinetics of the mitochondrial NADH-ubiquinone oxidoreductase interaction with hexammineruthenium(III)". Biochim. Biophys. Acta. 1141 (2–3): 262–8. doi:10.1016/0005-2728(93)90051-G. PMID 8443212.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Berry A, Scott HS, Kudoh J, et al. (2001). "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region". Genomics. 68 (1): 22–9. doi:10.1006/geno.2000.6253. PMID 10950923.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zakharova NV, Zharova TV (2003). "Kinetic mechanism of mitochondrial NADH:ubiquinone oxidoreductase interaction with nucleotide substrates of the transhydrogenase reaction". Biochemistry Mosc. 67 (12): 1395–404. doi:10.1023/A:1021818312040. PMID 12600270. S2CID 25862860.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kervinen M, Hinttala R, Helander HM, et al. (2006). "The MELAS mutations 3946 and 3949 perturb the critical structure in a conserved loop of the ND1 subunit of mitochondrial complex I". Hum. Mol. Genet. 15 (17): 2543–52. doi:10.1093/hmg/ddl176. PMID 16849371.