Myeloproliferative neoplasms (MPNs) are a group of rare blood cancers in which excess red blood cells, white blood cells or platelets are produced in the bone marrow. Myelo refers to the bone marrow, proliferative describes the rapid growth of blood cells and neoplasm describes that growth as abnormal and uncontrolled.
|Other names||Myeloproliferative diseases (MPDs)|
|Myelogram of someone with a myeloproliferative disorder.|
|Specialty||Hematology and oncology|
MPNs arise when precursor cells (blast cells) of the myeloid lineages in the bone marrow develop somatic mutations which cause them to grow abnormally. There is a similar category of disease for the lymphoid lineage, the lymphoproliferative disorders acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma.
People with MPNs might not have symptoms when their disease is first detected via blood tests.
Depending on the nature of the myeloproliferative neoplasm, diagnostic tests may include red cell mass determination (for polycythemia), bone marrow aspirate and trephine biopsy, arterial oxygen saturation and carboxyhaemoglobin level, neutrophil alkaline phosphatase level, vitamin B12 (or B12 binding capacity), serum urate or direct sequencing of the patient's DNA.
According to WHO diagnostic criteria published in 2016, myeloproliferative neoplasms are diagnosed as follows:
Chronic myeloid leukemiaEdit
Chronic neutrophilic leukemiaEdit
Essential thrombocythemia (ET) is diagnosed with a platelet count greater than 450 × 109/L and is associated with the JAK2 V617F mutation in up to 55% of cases and with an MPL (thrombopoietin receptor) mutation in up to 5% of cases:. There should be no increase in reticulin fibers and the patient should not meet the criteria for other MPNs, in particular Pre-PMF.
Polycythemia vera (PV) is associated most often with the JAK2 V617F mutation in greater than 95% of cases, whereas the remainder have a JAK2 exon 12 mutation. High hemoglobin or hematocrit counts are required, as is a bone marrow examination showing "prominent erythroid, granulocytic and megakaryocytic proliferation with pleomorphic, mature megakaryocytes."
Prefibrotic/early primary myelofibrosisEdit
Pre-PMF is typically associated with JAK2, CALR, or MPL mutations and shows a reticulin fibrosis no greater than grade 1. Anemia, splenomegaly, LDH above the upper limits and leukocytosis are minor criteria.
Overtly fibrotic myelofibrosisEdit
Like Pre-PMF, overt Primary myelofibrosis is associated with JAK2, CALR, or MPL mutations. However, Bone marrow examination will show reticulin and/or collagen fibrosis with a grade 2 or 3. Anemia, splenomegaly, LDH above the upper limits and leukocytosis are minor criteria.
Patients with otherwise unexplained thrombosis and with neoplasms that can't be classified in one of the other categories.
Incidence and PrevalenceEdit
Although considered rare diseases, incidence rates of MPNs are increasing, in some cases tripling. It is hypothesized that the increase may be related to improved diagnostic abilities from the identification of the JAK2 and other gene markers, as well as continued refinement of the WHO guidelines. 
No curative drug treatment exists for MPNs. Hematopoietic stem cell transplantation can be a curative treatment for a small group of patients, however MPN treatment is typically focused on symptom control and myelosuppressive drugs to help control the production of blood cells.
The goal of treatment for ET and PV is prevention of thrombohemorrhagic complications. The goal of treatment for MF is amelioration of anemia, splenomegaly, and other symptoms. Low-dose aspirin is effective in PV and ET. Tyrosine kinase inhibitors like imatinib have improved the prognosis of CML patients to near-normal life expectancy.
Recently, a JAK2 inhibitor, namely ruxolitinib, has been approved for use in primary myelofibrosis. Trials of these inhibitors are in progress for the treatment of the other myeloproliferative neoplasms.
The concept of myeloproliferative disease was first proposed in 1951 by the hematologist William Dameshek. The discovery of the association of MPNs with the JAK2 gene marker in 2005 and the CALR marker in 2013 improved the ability to classify MPNs. 
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- Myeloproliferative+Disorders at the US National Library of Medicine Medical Subject Headings (MeSH)
- MPN Cancer Connection
- MPN Research Foundation
- Myeloproliferative Disorders Website of The CMPD Education Foundation
- Myeloproliferative Disorders in practice
- Myeloproliferative Disorders Research Consortium
- MPN Info via Cancer.gov
- PV Reporter
- Spotlight on MPN