Muscle fatigue is the decline in ability of muscles to generate force. It can be a result of vigorous exercise but abnormal fatigue may be caused by barriers to or interference with the different stages of muscle contraction. There are two main causes of muscle fatigue: the limitations of a nerve’s ability to generate a sustained signal (neural fatigue); and the reduced ability of the muscle fiber to contract (metabolic fatigue).
Muscle cells work by detecting a flow of electrical impulses from the brain which signals them to contract through the release of calcium by the sarcoplasmic reticulum. Fatigue (reduced ability to generate force) may occur due to the nerve, or within the muscle cells themselves.
Nerves are responsible for controlling the contraction of muscles, determining the number, sequence and force of muscular contraction. Most movements require a force far below what a muscle could potentially generate, and nervous fatigue is seldom an issue. But, during extremely powerful contractions that are close to the upper limit of a muscle's ability to generate force, nervous fatigue (enervation) — in which the nerve signal weakens — can be a limiting factor in untrained individuals.
In novice strength trainers, the muscle's ability to generate force is most strongly limited by nerve’s ability to sustain a high-frequency signal. After a period of maximum contraction, the nerve’s signal reduces in frequency and the force generated by the contraction diminishes. There is no sensation of pain or discomfort, the muscle appears to simply ‘stop listening’ and gradually cease to contract, often going backwards. Often there is insufficient stress on the muscles and tendons to cause delayed onset muscle soreness following the workout.
Part of the process of strength training is increasing the nerve's ability to generate sustained, high frequency signals which allow a muscle to contract with its greatest force. This neural training can cause several weeks of rapid gains in strength, which level off once the nerve is generating maximum contractions and the muscle reaches its physiological limit. Past this point, training effects increase muscular strength through myofibrillar or sarcoplasmic hypertrophy and metabolic fatigue becomes the factor limiting contractile force.
Though not universally used, ‘metabolic fatigue’ is a common term for the reduction in contractile force due to the direct or indirect effects of two main factors:
- Shortage of fuel (substrates) within the muscle fiber
- Accumulation of substances (metabolites) within the muscle fiber, which interfere either with the release of calcium (Ca2+) or with the ability of calcium to stimulate muscle contraction.
Substrates within the muscle serve to power muscular contractions. They include molecules such as adenosine triphosphate (ATP), glycogen and creatine phosphate. ATP binds to the myosin head and causes the ‘ratchetting’ that results in contraction according to the sliding filament model. Creatine phosphate stores energy so ATP can be rapidly regenerated within the muscle cells from adenosine diphosphate (ADP) and inorganic phosphate ions, allowing for sustained powerful contractions that last between 5–7 seconds. Glycogen is the intramuscular storage form of glucose, used to generate energy quickly once intramuscular creatine stores are exhausted, producing lactic acid as a metabolic byproduct.
Substrate shortage is one of the causes of metabolic fatigue. Substrates are depleted during exercise, resulting in a lack of intracellular energy sources to fuel contractions. In essence, the muscle stops contracting because it lacks the energy to do so.
Metabolites are the substances (generally waste products) produced as a result of muscular contraction. They include chloride, potassium, lactic acid, ADP, magnesium (Mg2+), reactive oxygen species, and inorganic phosphate. Accumulation of metabolites can directly or indirectly produce metabolic fatigue within muscle fibers through interference with the release of calcium (Ca2+) from the sarcoplasmic reticulum or reduction of the sensitivity of contractile molecules actin and myosin to calcium.
Intracellular chloride partially inhibits the contraction of muscles. Namely, it prevents muscles from contracting due to "false alarms", small stimuli which may cause them to contract (akin to myoclonus).
High concentrations of potassium (K+) also causes the muscle cells to decrease in efficiency, causing cramping and fatigue. Potassium builds up in the t-tubule system and around the muscle fiber as a result of action potentials. The shift in K+ changes the membrane potential around the muscle fiber. The change in membrane potential causes a decrease in the release of calcium (Ca2+) from the sarcoplasmic reticulum.
It was once believed that lactic acid build-up was the cause of muscle fatigue. The assumption was lactic acid had a "pickling" effect on muscles, inhibiting their ability to contract. Though the impact of lactic acid on performance is now uncertain, it may assist or hinder muscle fatigue.
Produced as a by-product of fermentation, lactic acid can increase intracellular acidity of muscles. This can lower the sensitivity of contractile apparatus to Ca2+ but also has the effect of increasing cytoplasmic Ca2+ concentration through an inhibition of the chemical pump that actively transports calcium out of the cell. This counters inhibiting effects of potassium on muscular action potentials. Lactic acid also has a negating effect on the chloride ions in the muscles, reducing their inhibition of contraction and leaving potassium ions as the only restricting influence on muscle contractions, though the effects of potassium are much less than if there were no lactic acid to remove the chloride ions. Ultimately, it is uncertain if lactic acid reduces fatigue through increased intracellular calcium or increases fatigue through reduced sensitivity of contractile proteins to Ca2+.
Muscle weakness may be due to problems with the nerve supply, neuromuscular disease (such as myasthenia gravis) or problems with muscle itself. The latter category includes polymyositis and other muscle disorders.
Muscle fatigue may be due to precise molecular changes that occur in vivo with sustained exercise. It has been found that the ryanodine receptor present in skeletal muscle undergoes a conformational change during exercise, resulting in "leaky" channels that are deficient in calcium release. These "leaky" channels may be a contributor to muscle fatigue and decreased exercise capacity.
Effect on performanceEdit
Fatigue has been found to play a big role in limiting performance in just about every individual in every sport. In research studies, participants were found to show reduced voluntary force production in fatigued muscles (measured with concentric, eccentric, and isometric contractions), vertical jump heights, other field tests of lower body power, reduced throwing velocities, reduced kicking power and velocity, less accuracy in throwing and shooting activities, endurance capacity, anaerobic capacity, anaerobic power, mental concentration, and many other performance parameters when sport specific skills are examined.
Electromyography is a research technique that allows researchers to look at muscle recruitment in various conditions, by quantifying electrical signals sent to muscle fibers through motor neurons. In general, fatigue protocols have shown increases in EMG data over the course of a fatiguing protocol, but reduced recruitment of muscle fibers in tests of power in fatigued individuals. In most studies, this increase in recruitment during exercise correlated with a decrease in performance (as would be expected in a fatiguing individual).
Median power frequency is often used as a way to track fatigue using EMG. Using the median power frequency, raw EMG data is filtered to reduce noise and then relevant time windows are Fourier Transformed. In the case of fatigue in a 30-second isometric contraction, the first window may be the first second, the second window might be at second 15, and the third window could be the last second of contraction (at second 30). Each window of data is analyzed and the median power frequency is found. Generally, the median power frequency decreases over time, demonstrating fatigue. Some reasons why fatigue is found are due to action potentials of motor units having a similar pattern of repolarization, fast motor units activating and then quickly deactivating while slower motor units remain, and conduction velocities of the nervous system decreasing over time.
- Dee Unglaub Silverthorn (2009). Human Physiology: An Integrated Approach (5th ed.). Pearson. p. 412. ISBN 978-0321559807.
- Sahlin K (1986). "Muscle fatigue and lactic acid accumulation". Acta Physiol Scand Suppl. 556: 83–91. PMID 3471061.
- Lundby C, Robach P (July 2015). "Performance Enhancement: What Are the Physiological Limits?". Physiology. 30 (4): 282–92. doi:10.1152/physiol.00052.2014. PMID 26136542.
- Bellinger AM, Reiken S, Dura M, Murphy PW, Deng SX, Landry DW, Nieman D, Lehnart SE, Samaru M, LaCampagne A, Marks AR (February 2008). "Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity". Proc. Natl. Acad. Sci. U.S.A. 105 (6): 2198–202. Bibcode:2008PNAS..105.2198B. doi:10.1073/pnas.0711074105. PMC 2538898. PMID 18268335.
- Knicker AJ, Renshaw I, Oldham AR, Cairns SP (April 2011). "Interactive processes link the multiple symptoms of fatigue in sport competition" (PDF). Sports Med. 41 (4): 307–28. doi:10.2165/11586070-000000000-00000. PMID 21425889. S2CID 20840531.
- Montgomery PG, Pyne DB, Hopkins WG, Dorman JC, Cook K, Minahan CL (September 2008). "The effect of recovery strategies on physical performance and cumulative fatigue in competitive basketball". J Sports Sci. 26 (11): 1135–45. doi:10.1080/02640410802104912. PMID 18608847. S2CID 37412777.
- Linnamo V, Häkkinen K, Komi PV (1998). "Neuromuscular fatigue and recovery in maximal compared to explosive strength loading". Eur J Appl Physiol Occup Physiol. 77 (1–2): 176–81. doi:10.1007/s004210050317. PMID 9459539. S2CID 27621985.
- Smilios I, Häkkinen K, Tokmakidis SP (August 2010). "Power output and electromyographic activity during and after a moderate load muscular endurance session". J Strength Cond Res. 24 (8): 2122–31. doi:10.1519/JSC.0b013e3181a5bc44. PMID 19834352. S2CID 25256350.
- Girard O, Lattier G, Micallef JP, Millet GP (June 2006). "Changes in exercise characteristics, maximal voluntary contraction, and explosive strength during prolonged tennis playing". Br J Sports Med. 40 (6): 521–6. doi:10.1136/bjsm.2005.023754. PMC 2465109. PMID 16720888.
- Carneiro JG, Gonçalves EM, Camata TV, Altimari JM, Machado MV, Batista AR, Guerra Junior G, Moraes AC, Altimari LR (2010). "Influence of gender on the EMG signal of the quadriceps femoris muscles and performance in high-intensity short-term exercise". Electromyogr Clin Neurophysiol. 50 (7–8): 326–32. PMID 21284370.
- Clark BC, Manini TM, Thé DJ, Doldo NA, Ploutz-Snyder LL (June 2003). "Gender differences in skeletal muscle fatigability are related to contraction type and EMG spectral compression". J. Appl. Physiol. 94 (6): 2263–72. doi:10.1152/japplphysiol.00926.2002. PMID 12576411. S2CID 16202462.
- Beneka AG, Malliou PK, Missailidou V, Chatzinikolaou A, Fatouros I, Gourgoulis V, Georgiadis E (2013). "Muscle performance following an acute bout of plyometric training combined with low or high intensity weight exercise". J Sports Sci. 31 (3): 335–43. doi:10.1080/02640414.2012.733820. PMID 23083331. S2CID 31326593.
- Pincivero DM, Aldworth C, Dickerson T, Petry C, Shultz T (April 2000). "Quadriceps-hamstring EMG activity during functional, closed kinetic chain exercise to fatigue". Eur. J. Appl. Physiol. 81 (6): 504–9. doi:10.1007/s004210050075. PMID 10774875. S2CID 9033212.
- Jakobsen MD, Sundstrup E, Andersen CH, Zebis MK, Mortensen P, Andersen LL (September 2012). "Evaluation of muscle activity during a standardized shoulder resistance training bout in novice individuals". J Strength Cond Res. 26 (9): 2515–22. doi:10.1519/JSC.0b013e31823f29d9. PMID 22067242. S2CID 17445280.
- Sundstrup E, Jakobsen MD, Andersen CH, Zebis MK, Mortensen OS, Andersen LL (July 2012). "Muscle activation strategies during strength training with heavy loading vs. repetitions to failure". J Strength Cond Res. 26 (7): 1897–903. doi:10.1519/JSC.0b013e318239c38e. PMID 21986694. S2CID 5587233.
- Cardozo AC, Gonçalves M, Dolan P (December 2011). "Back extensor muscle fatigue at submaximal workloads assessed using frequency banding of the electromyographic signal". Clin Biomech (Bristol, Avon). 26 (10): 971–6. doi:10.1016/j.clinbiomech.2011.06.001. PMID 21696871.
- Hollman JH, Hohl JM, Kraft JL, Strauss JD, Traver KJ (May 2013). "Does the fast Fourier transformation window length affect the slope of an electromyogram's median frequency plot during a fatiguing isometric contraction?". Gait Posture. 38 (1): 161–4. doi:10.1016/j.gaitpost.2012.10.028. PMID 23211923.