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The Mugello is a historic region and valley in northern Tuscany, in Italy, corresponding to the course of the River Sieve. It is located to the north of the city of Florence and includes the northernmost portion of the Metropolitan City of Florence. The Futa Pass connects the Mugello valley to the separate Santerno river valley.
The Mugello valley was settled by a Ligurian tribe known as the Magelli, hence the name. Then the region was occupied by the Etruscans who have left many archaeological traces and who built the first road network of the Mugello.
The subsequent Ancient Roman conquest and colonization of the Mugello region dates back to the 4th century BCE. It is not only testified by several finds such as tombs, coins, and walls, but also, through toponymy, e.g. names of places ending with the praedial suffix -ano (Latin -anus) or -ana: Cerliano, Figliano, Marcoiano, Galliano, Lucignano, etc.
In the Middle Ages the Mugello was home to numerous castles. The Mugello region was later acquired by the Republic of Florence. Several patrician families of the area built villas here, such as those of the Medici including Villa Medicea di Cafaggiolo and Villa Medicea del Trebbio.