Mr. Mystic is a comics series featuring a magician crime-fighter, created by Will Eisner and initially drawn by Bob Powell. The strip featured in four-page backup feature a Sunday-newspaper comic-book insert, known colloquially as "The Spirit Section". It first appeared in 1940, distributed by the Register and Tribune Syndicate.
Along with the series Lady Luck, the Mr. Mystic strip followed the seven-page lead feature The Spirit in a 16-page, tabloid-sized, newsprint comic book sold as part of eventually 20 Sunday newspapers with a combined circulation of as many as five million copies. "The Spirit Section" premiered on June 2, 1940 and continued through 1952. Mr. Mystic ended May 14, 1944, by which time Fred Guardineer had succeeded Powell on the strip.
Unlike the newspaper series The Spirit or Lady Luck, Mr. Mystic was not later reprinted in standard comic books by publisher Quality Comics, and considered the least successful, it was the first of the three series to end.
During the 1970s and 80s, several Mr. Mystic stories were reprinted in the black-and-white magazine The Spirit, during the Kitchen Sink Press portion of the magazine's run. In 1990, Eclipse Comics published a one-shot comic book reprinting the first five Mr. Mystic stories.
Mr. Mystic also appears as a regular character in Will Eisner's John Law: Dead Man Walking (2004, IDW), a collection of stories that features new adventures by writer/artist Gary Chaloner. The book features other Eisner creations including Lady Luck, John Law and Nubbin, the Shoe Shine Boy.
Mr. Mystic, whose alter ego was simply named Ken, gained his superpowers in Tibet after receiving a tattoo of an arcane symbol on his forehead. Among his abilities were the power to transform into animals and to grow to giant or minute sizes. Attired in stage magician clothing plus a turban, he fought crime in the United States.
After The Spirit, perhaps the best drawn feature in the section was Powell's Mr. Mystic. Eisner created Mr. Mystic by retooling his Yarko the Great, which had been syndicated overseas. After running through Eisner's scripts, Powell wrote and drew the feature until he was drafted a couple of years later. (A very good artist, Powell was a journeyman writer who tried but never managed to sell Eisner on some Spirit scripts, a situation that rankled Powell for some time).— Heintjes, Tom 
- Mr.Mystic at Don Markstein's Toonopedia Archived from the original on March 10, 2016.
- Mr. Mystic at Wildwood Cemetery: The Spirit Database. WebCitation archive.
- "The Spirit: Writing the Rules", in The Spirit: The Origin Years #4 (Kitchen Sink Press, November 1992), via archive of reprinted article at AdventureStrips.com.