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Mitochondrial ribosomal protein l13

Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene. [5]

MRPL13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL13, L13, L13A, L13mt, RPL13, RPML13, mitochondrial ribosomal protein L13
External IDsOMIM: 610200 MGI: 2137218 HomoloGene: 90894 GeneCards: MRPL13
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for MRPL13
Genomic location for MRPL13
Band8q24.12Start120,380,761 bp[1]
End120,445,402 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014078

NM_026759

RefSeq (protein)

NP_054797

NP_081035

Location (UCSC)Chr 8: 120.38 – 120.45 MbChr 15: 55.53 – 55.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FunctionEdit

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172172 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022370 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mitochondrial ribosomal protein L13". Retrieved 2017-07-05.

Further readingEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.