Route 254 begins at an intersection with Route 83 south of Wheatland, heading east on a two-lane undivided road. The route passes through agricultural areas with some trees, turning south before heading east. The road heads into more wooded areas with some development, curving northeast before turning back to the east and passing through the community of Galmey. Route 254 curves southeast and east through more woodland with some homes. The road curves northeast before a turn to the east, passing to the north of Pomme de Terre Lake. The route heads northeast and crosses the Pomme de Terre Dam, which forms the lake. Route 254 heads east through more woods and passes a few businesses before coming to an intersection with the western terminus of Route 64. Here, Route 254 turns to the north before curving northwest and passing through a mix of fields and woods with some development. The road heads north through more rural areas before entering Hermitage, where it becomes Jackson Street and passes homes and businesses. Route 254 comes to its eastern terminus at an intersection with US 54.