In molecular biology mir-598 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-598 | |
|---|---|
| Identifiers | |
| Symbol | mir-598 |
| Rfam | RF01059 |
| miRBase family | MIPF0000393 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
miR-598 in senescence edit
miR-598 has been shown to directly target and inhibit the Sir2 homolog, silent information regulator one (SRT1) enzyme, in the senescence of human adipose-tissue-derived mesenchymal stem cells. Increased miR-598 expression during the senescent state is accompanied by a decreased expression of SRT1, meaning an absence of the inhibited p53 acetylation usually observed with increased STR1 levels.[1] miR-598 acts to modulate cellular senescence. More specifically, its overexpression induces senescence in early-passage cells whilst inhibition conversely sees a partial recovery of the ageing phenotype through increased cellular differentiation.
See also edit
References edit
- ^ Shin KK, Kim YJ, Hong CP, Yang JW, Bae YC, Jung JS (2012). "miR-598 induces replicative senescence in human adipose tissue-derived mesenchymal stem cells via silent information regulator 1". Mol Cell Biochem. 372 (1–2): 285. doi:10.1007/s11010-012-1330-y. PMID 22581440.
Further reading edit
- Mosakhani, N.; Guled, M.; Leen, G.; Calabuig-Fariñas, S.; Niini, T.; Machado, I.; Savola, S.; Scotlandi, K.; López-Guerrero, J.; Llombart-Bosch, A.; Knuutila, S. (2012). "An integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma". Journal of Experimental & Clinical Cancer Research. 31 (1): 24. doi:10.1186/1756-9966-31-24. PMC 3338077. PMID 22429812.
- Girardi, C.; De Pittà, C.; Casara, S.; Sales, G.; Lanfranchi, G.; Celotti, L.; Mognato, M. (2012). Battista, John R (ed.). "Analysis of miRNA and mRNA Expression Profiles Highlights Alterations in Ionizing Radiation Response of Human Lymphocytes under Modeled Microgravity". PLOS ONE. 7 (2): e31293. Bibcode:2012PLoSO...731293G. doi:10.1371/journal.pone.0031293. PMC 3276573. PMID 22347458.
External links edit
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