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Mittermeier was born in Dorfen, Upper Bavaria. During his childhood he lived in Bavaria. After school he studied theatre. In 1996, he started the comedy program Zapped. Zapped (1996) was shown on his tours in Germany, Austria and Switzerland. He participated in comedy television shows as well as the German TV show Wetten, dass..?. The most well-known parts of Zapped are parodies of German advertisements as well as the US television series MacGyver, which later became a running gag. Mittermeier popularized the term “Arschgeweih” (literally: ass antler) (tramp stamp). His next comedy programs were Wahnsinnlich (1990), Zapped! (1999), Back to Life (2002), Paranoid (2004), Safari (2007) and Achtung, Baby! (2010).
In 2001, he was featured in the music video for the Guano Apes (credited here as the Guano Babes) song, "Kumba Yo".
Mittermeier was also involved in the 2010 documentary This Prison Where I Live, featuring the Burmese comedian Zarganar who was imprisoned by his country's military junta for lampooning and criticizing them.
Having been born (and brought up) in Bavaria, Mittermeier has also been a lifelong fan of the soccer team Bayern Munich.
In 1998 he published Im Rausch der Kanäle (together with Thomas Hermanns and Gudrun Allwang.)
In 2010 he published Achtung, Baby!
- Grazer Kleinkunstvogel
- Prix Pantheon
- 1996: Publikumspreis Beklatscht & Ausgebuht
- Goldene Europa
- 1998: Category Comedy
- Deutscher Comedypreis
- 1999: Best Comedian (Publikumspreis)
- 2000: Best Comedian (Publikumspreis)
- 2002: Best Live-Comedy for „Back to life“
- 2004: Best Live-Comedy
- 2008: Best Comedian
- Eins Live Krone (WDR)
- 2000: Best Comedian
- 2001: Best Comedian
- 2001: Category Comedy
- Schneestern von Arosa
- 2005: Award