Methylclostebol, also known as 4-chloro-17α-methyltestosterone or as 4-chloro-17α-methylandrost-4-en-17β-ol-3-one, is a synthetic, orally active anabolic-androgenic steroid (AAS) and designer steroid that has been sold on the Internet as a "dietary supplement",[1][2] but it has never been studied for medical use.[3] It is the 17α-alkylated variant of clostebol (4-chlorotestosterone).[4]

Clinical data
Other namesChloromethyltestosterone; CMT; 4-Chloro-17α-methyltestosterone; 4-Chloro-17α-methylandrost-4-en-17β-ol-3-one
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PubChem CID
Chemical and physical data
Molar mass336.90 g·mol−1
3D model (JSmol)

Rahnema, Crosnoe, and Kim (2015) reported that German athletes used methylclostebol as a performance enhancing drug in the 1960s and 1970s, but this has not been substantiated.[3] The compound is listed as a banned anabolic agent by the World Anti-Doping Agency.[5]

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  1. ^ Rahnema CD, Crosnoe LE, Kim ED (2015). "Designer steroids - over-the-counter supplements and their androgenic component: review of an increasing problem". Andrology. 3 (2): 150–5. doi:10.1111/andr.307. PMID 25684733. S2CID 6999218.
  2. ^ Pope HG, Wood RI, Rogol A, Nyberg F, Bowers L, Bhasin S (2014). "Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement". Endocr. Rev. 35 (3): 341–75. doi:10.1210/er.2013-1058. PMC 4026349. PMID 24423981.
  3. ^ a b Rahnema, C. D.; Crosnoe, L. E.; Kim, E. D. (2015). "Designer steroids - over-the-counter supplements and their androgenic component: Review of an increasing problem". Andrology. 3 (2): 150. doi:10.1111/andr.307. PMID 25684733. S2CID 6999218.
  4. ^ Lootens, L., Van Eenoo, P., Pozo Mendoza, O. J., Meulemans, P., Leroux-Roels, G., & Delbeke, F. (2010). Application of in vivo urinary steroid detection in uPA+/+-SCID chimeric mice. In 28th Cologne workshop on Dope Analysis (Manfred Donike workshop) (Vol. 18, pp. 52-61). Sportverlag Strauss.
  5. ^ "World Anti-Doping Code: International Standard Prohibited List" (PDF). January 2017.