Mesh-He (r.c. 2588 BC – c. 2552 BC) is the 10th lugal of the first dynasty of Uruk. He ruled in modern-day Mesopotamia. Little is known about Mesh-he.

The Sumerian King List puts him after En-Nun-Tarah-Ana and assigns 36 years of reign, it is believed he died by the year 2552 BC. He was followed by Melem-ana.

His historicity, and that of his successors, however, is not completely established.

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Regnal titles
Preceded by King of Sumer
ca. 26th century BC
Succeeded by
Ensi[citation needed] of Uruk
ca. 26th century BC