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Fictional character biographyEdit

Ophelia SarkissianEdit

Sixth Madame HydraEdit

Madame Hydra
Publication information
PublisherMarvel Comics
First appearanceNick Fury vs. S.H.I.E.L.D. #3 (Aug 1988)
Created byBob Harras
Paul Neary
In-story information
Team affiliationsHydra

The sixth Madame Hydra was created by Bob Harras and Paul Neary, and debuted in Nick Fury vs. S.H.I.E.L.D. #3 (Aug 1988). Madame Hydra received an entry in the Official Handbook of the Marvel Universe Update '89 #4, under the heading "Madame Hydra VI".

This operative of Hydra impressed her superiors enough that, after only a short time in the organization, they promoted her to the level of Madame Hydra VI (The identities of Madames Hydra I through V, who rank above her, are unknown). One of her first missions as Madame Hydra was to capture Nick Fury and deliver him to the Deltites, a group of artificially created duplicates which were taking over S.H.I.E.L.D. After failing in her mission and discovering that the Deltites were manipulating her, she allied with the S.H.I.E.L.D. agents against the takeover. She was later turned over to federal authorities and was found to be criminally insane, and sent to Arnold Sanitarium for psychiatric treatment (the same sanitarium that Bigfoot was later imprisoned in).[1]

Valentina Allegra de FontaineEdit

Valentina Allegra de Fontaine succeeded Viper as Madame Hydra. She wears an elaborate tentacle headdress and elaborate Hydra robes.[2]

Elisa SinclairEdit

Elisa Sinclair has appeared in Captain America's implanted memories that Red Skull's clone and Kobik placed in him to make Captain America think that he is a Hydra sleeper agent. She is depicted as an ancient being with magical powers that had an extensive reach.[3]

In the present, Elisa intercepts Taskmaster and Eric O'Grady's Life Model Decoy counterpart Black Ant who were on their way to present evidence of Captain America's brainwashing to Maria Hill.[4] After keeping Taskmaster and Black Ant alive and persuading them to become her personal guards, Elisa then collects a new Hydra High Council consisting of herself, a new Kraken, Gorgon, Hive, Viper, Baron Helmut Zemo, Arnim Zola, and Doctor Faustus.[5]

During the "Opening Salvo" part of the Secret Empire storyline, Elisa reunites with Captain America after he overthrew Red Skull for leadership of Hydra.[6] While in her study room following Hydra's takeover of the United States, Elisa uses her magic spells to counter every one of Doctor Strange's attempts to bring down the Darkforce dome that is surrounding Manhattan. While having tea with Captain America, Elisa is informed of Captain America's suspicion about Baron Zemo and Doctor Faustus' disloyalty. Elisa brushes off the suspicion and tells Captain America that they plan to assemble the Cosmic Cube in order to restore Earth to their vision.[7] Elisa later gives Captain America the updates on the members of Hydra's Avengers. She tells him that Scarlet Witch has become unhinged due to her being possessed by Chthon, Vision is still kept under Hydra's control through Arnim Zola's A.I. Virus, and Odinson is still praying to Odin about his troubles like Jane Foster being trapped in an alternate reality. As Captain America prepares to leave, Elisa tells Captain America that he has become like a son to her.[8] During Hydra's attack on the Underground's base at the Mount, Elisa detects an unusual amount of energy in the Mount and rushes in. Madame Hydra arrives and teleports Captain America away at the last second as the Tony Stark A.I. explodes where it destroys the base and Madame Hydra.[9]

Other versionsEdit

Heroes RebornEdit

In the Heroes Reborn reality, Madame Hydra is a terrorist leader. She answers to Hydra's leader Mandarin, who is actually a robot built by Doctor Doom.[10] She is killed in battle against Iron Man.[11]

In other mediaEdit


  • Viper appears as Madame Hydra in X-Men: Evolution, voiced by Lisa Ann Beley. As seen in "Target X", she is the leader of Hydra and is served by Gauntlet. Viper is apparently killed when her base is destroyed by X-23.
  • Viper appears as Madame Hydra in the Spider-Woman: Agent of S.W.O.R.D. motion comic, voiced by Nicolette Reed.[12]
  • Viper appears in The Avengers: Earth's Mightiest Heroes, voiced by Vanessa Marshall.[13] She officially appears in the episode "Prisoner of War". In the episode "Widow's Sting", she is captured by S.H.I.E.L.D., and is revealed to be a Skrull in disguise. In the episode "Prisoner of War", the real Viper was shown to be held captive in the Skrull ship, but was freed by Captain America and is forced to escape from the Skrull ship. She has a cameo appearance in the episode "Secret Invasion" and is shown aiding the heroes in their fight against the Skrulls. Viper returns in the episode "Along Came A Spider" where she and King Cobra are rescued from S.H.I.E.L.D. by the Serpent Society, but are eventually recaptured by Captain America and Spider-Man.
Mallory Jansen as Madame Hydra, as depicted in Agents of S.H.I.E.L.D..
  • Madame Hydra appears in the alternate "Framework" reality depicted in the fourth season of Agents of S.H.I.E.L.D.. She appears as Aida's framework form (portrayed by Mallory Jansen).[14][15] Madame Hydra first appears in "What If..." where it is revealed that she is in control of keeping Daisy Johnson and Jemma Simmons in the Framework virtual reality in which Earth is ruled by Hydra. She is also in a relationship with Hydra's lead scientist Leo Fitz (known as The Doctor).[16] In the episode "Identity and Change", her real name in the Framework is revealed to be Ophelia, and she has been keeping Holden Radcliffe's consciousness isolated on Ogygia with the consciousness of her counterpart Agnes Kitsworth, until Agnes is "deleted" by The Doctor.[17] When Melinda May turns on Hydra and allows Daisy to go through terrigenesis, Daisy shoves Ophelia out a window, severely damaging her spine in the fall. Hospitalized, Ophelia tells Fitz that her body won't matter and that she will enact Project Looking Glass.[18] Upon being created in the real world, Ophelia kidnaps Fitz with her newfound teleportation ability.[19] Now experiencing human emotions including sympathy, she is convinced by Fitz to rescue Coulson, May and an unconscious Mack from drowning, but she and Fitz are captured by Simmons. Ophelia convinces Fitz that the decisions he made in the Framework were not his doing, but is jealous that Fitz still loves Simmons. Ophelia reveals that she is impervious to harm and displays electrical powers by killing off the S.H.I.E.L.D. agents who have come to rescue Fitz. She escapes and reunites with Anton Ivanov while making plans to make S.H.I.E.L.D. suffer for the pain they caused her.[20] In the episode "World's End", Ophelia attempts to retrieve the Darkhold, but is stopped by Robbie Reyes's unexpected arrival, the only person who can harm her. Phil Coulson borrows the Ghost Rider's powers in order to successfully destroy Ophelia once and for all.[21]


Video gamesEdit

Live performanceEdit


  • An action figure of Viper was released in the 2012 series of Marvel Legends figures from Hasbro, one of two figures using similar body molds (with different heads) marketed as "Marvel's Madames", the other figure being Madame Masque.


  1. ^ Nick Fury Vs. S.H.I.E.L.D. #6
  2. ^ Secret Warriors #3
  3. ^ Captain America: Steve Rogers #2
  4. ^ Captain America: Steve Rogers #12
  5. ^ Captain America: Steve Rogers #14
  6. ^ Captain America: Steve Rogers #16
  7. ^ Secret Empire #1
  8. ^ Secret Empire #5
  9. ^ Secret Empire #6
  10. ^ Iron Man Vol. 2 #1
  11. ^ Iron Man Vol. 2 #10
  12. ^ a b "Voice Of Madame Hydra – Captain America franchise | Behind The Voice Actors". Behind The Voice Actors. Retrieved September 25, 2018. Check mark indicates role has been confirmed using screenshots of closing credits and other reliable sources
  13. ^ Findlay, Kurtis (2010-04-26). "Avengers Images from C2E2". Retrieved 2010-08-16.
  14. ^ Abrams, Natalie (April 1, 2017). "Madame Hydra to appear on Agents of S.H.I.E.L.D. — first look". Entertainment Weekly. Archived from the original on April 2, 2017. Retrieved April 2, 2017. Cite uses deprecated parameter |deadurl= (help)
  15. ^ Abrams, Natalie (April 4, 2017). "Agents of S.H.I.E.L.D. boss on those Framework twists". Entertainment Weekly. Archived from the original on April 5, 2017. Retrieved April 5, 2017. Cite uses deprecated parameter |deadurl= (help)
  16. ^ Scott, Oz (director); DJ Doyle (writer) (April 4, 2017). "What If...". Marvel's Agents of S.H.I.E.L.D. Season 4. Episode 16. ABC.
  17. ^ Brown, Garry A. (director); George Kitson (writer) (April 11, 2017). "Identity and Change". Marvel's Agents of S.H.I.E.L.D. Season 4. Episode 17. ABC.
  18. ^ Gierhart, Billy (director); James C. Oliver and Sharla Oliver (writer) (April 25, 2017). "All the Madame's Men". Marvel's Agents of S.H.I.E.L.D. Season 4. Episode 19. ABC.
  19. ^ Misiano, Vincent (director); Brent Fletcher (writer) (May 2, 2017). "Farewell, Cruel World!". Marvel's Agents of S.H.I.E.L.D. Season 4. Episode 20. ABC.
  20. ^ Tancharoen, Kevin (director); Maurissa Tancharoen & Jed Whedon (writer) (May 9, 2017). "The Return". Marvel's Agents of S.H.I.E.L.D. Season 4. Episode 21. ABC.
  21. ^ Gierhart, Billy (director); Jeffrey Bell (writer) (May 16, 2017). "World's End". Marvel's Agents of S.H.I.E.L.D. Season 4. Episode 22. ABC.
  22. ^
  23. ^[permanent dead link]
  24. ^ Stoute, Scott (October 10, 2012). "New 'Wolverine' Set Images Show The Viper". Screen Rant. Retrieved July 14, 2017.
  25. ^ Jim Reilly (2010-10-05). "Captain America: Super Soldier Announced". Xbox 360 IGN. Retrieved 2011-01-11.
  26. ^ "LEGO Marvel Superheroes: Stan Lee Hulks Out – Comic-Con 2013". IGN. 20 July 2013. Retrieved 20 July 2013.
  27. ^ "Archived copy". Archived from the original on 2014-07-17. Retrieved 2014-06-29. Cite uses deprecated parameter |deadurl= (help)CS1 maint: archived copy as title (link)

External linksEdit