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Mitochondrial ribosomal protein L42

  (Redirected from MRPL42)

28S ribosomal protein L42, mitochondrial is a protein that in humans is encoded by the MRPL42 gene.[5][6][7]

MRPL42
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL42, L31MT, L42MT, MRP-L31, MRP-L42, MRP-S32, MRPL31, MRPS32, PTD007, RPML31, S32MT, HSPC204, Mitochondrial ribosomal protein L42
External IDsMGI: 1333774 HomoloGene: 12106 GeneCards: MRPL42
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for MRPL42
Genomic location for MRPL42
Band12q22Start93,467,488 bp[1]
End93,516,213 bp[1]
RNA expression pattern
PBB GE MRPL42 217919 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014050
NM_172177
NM_172178

NM_026065
NM_001359476
NM_001359477

RefSeq (protein)

NP_054769
NP_751917

NP_080341
NP_001346405
NP_001346406

Location (UCSC)Chr 12: 93.47 – 93.52 MbChr 10: 95.48 – 95.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Further experiments will be needed to identify the specific subunit localization. Sequence analysis identified three transcript variants that encode two different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q.[7]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198015 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062981 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  7. ^ a b "Entrez Gene: MRPL42 mitochondrial ribosomal protein L42".

Further readingEdit