MAP3K9

Mitogen-activated protein kinase kinase kinase 9 is an enzyme that in humans is encoded by the MAP3K9 gene.

MAP3K9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DTC, 4UY9
Identifiers
Aliases	MAP3K9, MEKK9, MLK1, PRKE1, mitogen-activated protein kinase kinase kinase 9
External IDs	OMIM: 600136 MGI: 2449952 HomoloGene: 76377 GeneCards: MAP3K9
Gene location (Human) Chr. Chromosome 14 (human) Band 14q24.2 Start 70,722,526 bp End 70,809,534 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 D1 Start 81,767,784 bp End 81,827,949 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis frontal pole postcentral gyrus amniotic fluid orbitofrontal cortex middle temporal gyrus Brodmann area 46 Region I of hippocampus proper superior frontal gyrus Brodmann area 23 Top expressed in superior frontal gyrus lip esophagus cerebellar cortex yolk sac secondary oocyte morula stomach neural tube ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity kinase activity protein serine/threonine kinase activity protein binding ATP binding MAP kinase kinase kinase activity MAP kinase kinase activity JUN kinase kinase kinase activity Cellular component cytoplasm cellular component intracellular anatomical structure Biological process regulation of transcription, DNA-templated phosphorylation cell death transcription, DNA-templated protein phosphorylation positive regulation of apoptotic process protein autophosphorylation apoptotic process MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4293 338372 Ensembl ENSG00000006432 ENSMUSG00000042724 UniProt P80192 Q3U1V8 RefSeq (mRNA) NM_001284230 NM_001284231 NM_001284232 NM_033141 NM_001174107 NM_177395 RefSeq (protein) NP_001271159 NP_001271160 NP_001271161 NP_149132 NP_001167578 NP_796369 Location (UCSC) Chr 14: 70.72 – 70.81 Mb Chr 12: 81.77 – 81.83 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Gallo KA, Mark MR, Scadden DT, et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity". J. Biol. Chem. 269 (21): 15092–100. doi:10.1016/S0021-9258(17)36578-X. PMID 8195146.
• Dorow DS, Devereux L, Dietzsch E, De Kretser T (1993). "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains". Eur. J. Biochem. 213 (2): 701–10. doi:10.1111/j.1432-1033.1993.tb17810.x. PMID 8477742.
• Dorow DS, Devereux L, Tu GF, et al. (1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur. J. Biochem. 234 (2): 492–500. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694.
• Xu Z, Maroney AC, Dobrzanski P, et al. (2001). "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis". Mol. Cell. Biol. 21 (14): 4713–24. doi:10.1128/MCB.21.14.4713-4724.2001. PMC 87148. PMID 11416147.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Durkin JT, Holskin BP, Kopec KK, et al. (2005). "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop". Biochemistry. 43 (51): 16348–55. doi:10.1021/bi049866y. PMID 15610029.

External links

• Overview of all the structural information available in the PDB for UniProt: P80192 (Mitogen-activated protein kinase kinase kinase 9) at the PDBe-KB.