Luis de Vega (? - Madrid, 1562) was a 16th-century Spanish architect appointed royal architect of Charles I. He renovated the old Alcazar of Madrid, the vanished royal residence,: 7 and transformed the pavilion on mount El Pardo, into what is now the Royal Palace of El Pardo.
With his nephew, the architect Gaspar de Vega, he worked on the vanished Palace of Valsaín and Torre de la Parada. In 1540 he designed the upper story of the "Patio de las Doncellas" (Courtyard of the Maidens) in the Alcázar of Seville.