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The first sequences of keratins revealed that keratins could be grouped into two categories based on their sequence homologies.[1][2] These two groups of keratins were named as type I and type II keratins.[2] These two categories also represent the first two categories of the superfamily of intermediate filament proteins.

Keratins in this table are classified in the first two columns according to the nomenclature established in 2006.[3] Other names previously used are listed in columns 3 and 4.

Type I keratinsEdit

Human epithelial keratinsEdit

Protein name[3] Gene name[3] Other protein name Other gene name
K9 KRT9 Ka9
K10 KRT10 Ka10
K12 KRT12 Ka12
K13 KRT13 Ka13
K14 KRT14 Ka14
K15 KRT15 Ka15
K16 KRT16 Ka16
K17 KRT17 Ka17
K18 KRT18 Ka18
K19 KRT19 Ka19
K20 KRT20 Ka20
K23 KRT23 Ka23
K24 KRT24 Ka24
K25 KRT25 Ka38, K25irs1, K10C, hIRSa1 KRT25A
K26 KRT26 Ka39, K25irs2, K10D
K27 KRT27 Ka40, K25irs3, K10B, hIRSa3.1
K28 KRT28 Ka41, K25irs4, hIRSa2

Human hair keratinsEdit

Protein name[3] Gene name[3] Other protein name Other gene name
K31 KRT31 Ka25, Ha1 KRTHA1
K32 KRT32 Ka26, Ha2 KRTHA2
K33a KRT33A Ka27, Ha3-I KRTHA3A
K33b KRT33B Ka28, Ha3-II KRTHA3B
K34 KRT34 Ka29, Ha4 KRTHA4
K35 KRT35 Ka30, Ha5 KRTHA5
K36 KRT36 Ka31, Ha6 KRTHA6
K37 KRT37 Ka32, Ha7 KRTHA7
K38 KRT38 Ka33, Ha8 KRTHA8
K39 KRT39 Ka35
K40 KRT40 Ka36

Nonhuman hair/epithelial keratinsEdit

Protein name[3] Gene name[3] Other protein name Other gene name
K41 chimp, gorilla KRT41 chimp, gorilla, KRT41P man φhHaA, Ka34P man
K42 mouse, rat KRT42 mouse, rat, KRT42P man Ka22 mouse, rat, K17n mouse, rat

Human keratin pseudogenesEdit

Protein name[3] Gene name[3] Other protein name Other gene name
KRT221P φhHaB
KRT222P φKRTI, Ka21P
KRT223P φKRTJ, Ka37P

Type II keratinsEdit

Human epithelial keratinEdit

Protein name[3] Gene name[3] Other protein name Other gene name
K1 KRT1 Kb1
K2 KRT2 Kb2, K2e KRT2A
K3 KRT3 Kb3
K4 KRT4 Kb4
K5 KRT5 Kb5
K6a KRT6A Kb6
K6b KRT6B Kb10
K7 KRT7 Kb7
K8 KRT8 Kb8
K71 KRT71 Kb34, K6irs1
K72 KRT72 Kb35, K6irs2
K73 KRT73 Kb36, K6irs3
K74 KRT74 Kb37, K6irs4
K75 KRT75 Kb18, K6hf
K76 KRT76 Kb9, K2p KRT2B
K77 KRT77 Kb39, K1b
K78 KRT78 Kb40, K5b
K79 KRT79 Kb38, K6I
K80 KRT80 Kb20

Human hair keratinsEdit

Protein name[3] Gene name[3] Other protein name Other gene name
K81 KRT81 Kb21, Hb1, K2.9 KRTHB1
K82 KRT82 Kb22, Hb2 KRTHB2
K83 KRT83 Kb23, Hb3, K2.10 KRTHB3
K84 KRT84 Kb24, Hb4 KRTHB4
K85 KRT85 Kb25, Hb5, K2.12 KRTHB5
K86 KRT86 Kb26, Hb6, K2.11 KRTHB6

Human keratin pseudogenesEdit

Protein name[3] Gene name[3] Other protein name Other gene name
KRT121P φhHbD, Kb31P
KRT122P φhHbC, Kb30P
KRT123P φhHbB, Kb29P
KRT124P φhHbA, Kb28P
KRT125P φKRTH
KRT126P φKRTG, Kb19P
KRT127P φKRTF
KRT128P φKRTE

See alsoEdit

ReferencesEdit

  1. ^ Hanukoglu, I.; Fuchs, E. (Nov 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell. 31 (1): 243–52. doi:10.1016/0092-8674(82)90424-X. PMID 6186381.
  2. ^ a b Hanukoglu, I.; Fuchs, E. (Jul 1983). "The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins" (PDF). Cell. 33 (3): 915–24. doi:10.1016/0092-8674(83)90034-X. PMID 6191871.
  3. ^ a b c d e f g h i j k l m n o Schweizer J, Bowden PE, Coulombe PA, et al. (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.