These are the number-one hits on the Top 100 Singles chart in 1980 as published by Cash Box magazine.
| † | Indicates best-performing single of 1980 |
| Issue date | Song | Artist |
|---|---|---|
| January 5 | "Escape (The Piña Colada Song)" | Rupert Holmes |
| January 12 | "Rock with You" | Michael Jackson |
| January 19 | ||
| January 26 | ||
| February 2 | "Do That to Me One More Time" | Captain & Tennille |
| February 9 | "Coward of the County" | Kenny Rogers |
| February 16 | "Cruisin'" | Smokey Robinson |
| February 23 | "Crazy Little Thing Called Love" | Queen |
| March 1 | ||
| March 8 | ||
| March 15 | "Longer" | Dan Fogelberg |
| March 22 | "Another Brick in the Wall (Part II)" | Pink Floyd |
| March 29 | ||
| April 5 | ||
| April 12 | "Call Me" | Blondie |
| April 19 | ||
| April 26 | ||
| May 3 | ||
| May 10 | ||
| May 17 | ||
| May 24 | ||
| May 31 | "Funkytown" | Lipps Inc |
| June 7 | ||
| June 14 | ||
| June 21 | ||
| June 28 | ||
| July 5 | "The Rose" | Bette Midler |
| July 12 | "It's Still Rock and Roll to Me" | Billy Joel |
| July 19 | ||
| July 26 | ||
| August 2 | "Magic" | Olivia Newton-John |
| August 9 | ||
| August 16 | ||
| August 23 | "Take Your Time (Do It Right)" | S.O.S. Band |
| August 30 | "Sailing" | Christopher Cross |
| September 6 | ||
| September 13 | "Upside Down" | Diana Ross |
| September 20 | ||
| September 27 | ||
| October 4 | "Another One Bites the Dust" † | Queen |
| October 11 | ||
| October 18 | ||
| October 25 | ||
| November 1 | "Woman in Love" | Barbra Streisand |
| November 8 | ||
| November 15 | "Lady" | Kenny Rogers |
| November 22 | ||
| November 29 | ||
| December 6 | "Master Blaster (Jammin')" | Stevie Wonder |
| December 13 | ||
| December 20 | "Lady" | Kenny Rogers |
| December 27 | "(Just Like) Starting Over" | John Lennon |