Isaacson collaborated with Lejaren Hiller on the computer-programmed acoustic composition, Illiac Suite (1957). At the time, both composers were professors at the University of Illinois at Urbana–Champaign, and used the university's room-size ILLIAC I.
- Hiller, Lejaren A., and Leonard M. Issacson. (1959/1979). Experimental Music: Composition With an Electronic Computer. McGraw-Hill, New York. ISBN 978-0-313-22158-3.