Wikipedia

Lankenau Institute for Medical Research

Lankenau Institute for Medical Research (LIMR), founded in 1927, is a nonprofit, biomedical research institute located on the campus of Lankenau Medical Center in Wynnewood, Pennsylvania, serving as the research division of the Main Line Health System in suburban Philadelphia.[1] LIMR focuses on studies of cancer, cardiovascular, autoimmune, gastrointestinal and other diseases. It houses a center for population health research.[2]

Lankenau Institute
for Medical Research
Established1927
President
and CEO		George C. Prendergast
AddressWynnewood, Pennsylvania
Websitewww.limr.org

History edit

LIMR was one of the first U.S. research institutes to focus on cancer when it was founded in 1927. It was formerly known as the Lankenau Hospital Research Institute (LHRI) until 1980 and the Lankenau Medical Research Center (LMRC) from 1981-1999.[3] Starting in 1941, LHRI also housed the Institute for Cancer Research (ICR), until the ICR was merged with the former American Oncology Hospital to create Fox Chase Cancer Center in 1974.[4][5]

LHRI researcher David Hungerford is credited with the discovery of the first genetic abnormality in cancer, called the Philadelphia chromosome.[6] It is detected in the vast majority of patients suffering from myelogenous leukemia. The first molecule-targeted drug to be created for cancer therapy, Gleevec (imatinib), acts by blocking this genetic abnormality.[citation needed]

LHRI researcher Baruch Blumberg is credited with the discovery of the hepatitis B virus and a blood test to detect it, as recognized by the 1976 Nobel Prize for Physiology or Medicine.[7]

LIMR carried out research into the role of IDO (indoleamine 2,3-dioxygenase) in cancer, including the first experimental therapeutics to directly inhibit this enzyme, which modifies inflammatory processes in cancer, autoimmune disease, retinopathy, cardiovascular disease, and other disorders.[8][9][10]

Background edit

George C. Prendergast is the President and CEO of LIMR since 2004.[11][12]

Grants and awards edit

  • National Institutes of Health (NIH) grant to Charles Antzelevitch for his proposal to develop new approaches for pharmacologic management of cardiac J Wave Syndromes.[13]
  • U.S. Department of Defense (DOD) grant to Ellen Heber-Katz for her study on drug-induced tissue regeneration and re-innervation after limb amputation.[14]
  • NIH grant to George Prendergast for his study: IDO2 targeting in pancreatic cancer.[15]
  • DOD grant to Susan Gilmour for her study: Targeting increased polyamine transport in drug-resistant melanoma.[16]
  • NIH grant to James Mullin for his study on the effects of the Ebola virus on the gastrointestinal tract.[17]
  • NIH grant to Scott Dessain for his study: Anti-NDMA receptor antibodies from patients with limbic encephalitis.[18]
  • NIH grant to Melvin Reichman for his study: New drug discovery paradigms for synucleinopathies.[19]
  • Giorgi Family Foundation grant to Laura Mandik-Nayak for her study on defining the role of IDO2 as a treatment for rheumatoid arthritis.[20]

References edit

  1. ^ "The man behind Lankenau Hospital". inquirer.com. Retrieved 30 August 2013.
  2. ^ "Main Line research institute turns to Jefferson for invention-licensing help". bizjournals.com. Retrieved 23 August 2019.
  3. ^ "The man behind Lankenau Hospital". inquirer.com. Retrieved 30 August 2013.
  4. ^ "Lankenau Institute For Medical Research - GovTribe". govtribe.com. Retrieved 21 September 2007.
  5. ^ "The man behind Lankenau Hospital". inquirer.com. Retrieved 30 August 2013.
  6. ^ Nowell, Peter C. (2007-08-01). "Discovery of the Philadelphia chromosome: a personal perspective". Journal of Clinical Investigation. 117 (8): 2033–2035. doi:10.1172/JCI31771. PMC 1934591. PMID 17671636.
  7. ^ "Physiology or Medicine 1976 - NobelPrize.org". nobelprize.org. Retrieved 22 December 2009.
  8. ^ Prendergast, G. C.; Malachowski, W. J.; Mondal, A.; Scherle, P.; Muller, A. J. (2018). "Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer". International Review of Cell and Molecular Biology. 336: 175–203. doi:10.1016/bs.ircmb.2017.07.004. ISBN 9780128146514. PMC 6054468. PMID 29413890.
  9. ^ Katz, J. B.; Muller, A. J.; Prendergast, G. C. (2008). "Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape". Immunological Reviews. 222: 206–221. doi:10.1111/j.1600-065X.2008.00610.x. PMID 18364004. S2CID 8133439. Retrieved 22 April 2008.
  10. ^ "10 ways Philadelphia is leading the war on cancer". bizjournals.com. Retrieved 17 April 2015.
  11. ^ "George C. Prendergast, PhD". mainlinehealth.org. Retrieved 18 June 2004.
  12. ^ "Jefferson and Lankenau Institute of Medical Research Collaborate on Cancer Research". Jefferson Surgical Solutions. 7 (2). 26 October 2012. Retrieved 26 October 2012.
  13. ^ Antzelevitch, C.; Yan, G. X.; Ackerman, M. J.; Borggrefe, M.; Corrado, D.; Guo, J.; Gussak, I.; Hasdemir, C.; Horie, M.; Huikuri, H.; Ma, C.; Morita, H.; Nam, G. B.; Sacher, F.; Shimizu, W.; Viskin, S.; Wilde, A. A. (2016). "J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge". Journal of Arrhythmia. 32 (5): 315–339. doi:10.1016/j.joa.2016.07.002. PMC 5063270. PMID 27761155.
  14. ^ Gourevitch, D.; Kossenkov, A. V.; Zhang, Y.; Clark, L.; Chang, C.; Showe, L. C.; Heber-Katz, E. (2014). "Inflammation and Its Correlates in Regenerative Wound Healing: An Alternate Perspective". Advances in Wound Care. 3 (9): 592–603. doi:10.1089/wound.2014.0528. PMC 4152783. PMID 25207202.
  15. ^ "IDO2 Targeting for pancreatic cancer treatment". grantome.com. Retrieved 1 November 2012.
  16. ^ "Targeting Increased Polyamine Transport of Resistant Melanomas" (PDF). apps.dtic.mil. Retrieved 7 September 2017.
  17. ^ Mullin, James M.; Raines, Jonathan; Livornese, Lawrence L. (2015). "Retrofitting the battlements: tight junction remodeling as a novel antimicrobial approach". Future Medicinal Chemistry. 7 (1): 9–13. doi:10.4155/fmc.14.146. PMID 25582329. Retrieved 13 January 2015.
  18. ^ Sharma, Rashmi; Al-Saleem, Fetweh H.; Panzer, Jessica; Lee, Jiwon; Puligedda, Rama Devudu; Felicori, Liza F.; Kattala, Chandana Devi; Rattelle, Amy J.; Ippolito, Gregory; Cox, Robert H.; Lynch, David R.; Dessain, Scott K. (2018). "Monoclonal antibodies from a patient with anti-NMDA receptor encephalitis". Annals of Clinical and Translational Neurology. 5 (8): 935–951. doi:10.1002/acn3.592. PMC 6093837. PMID 30128318.
  19. ^ "New Drug Discovery Paradigms for Synucleinopathies". grantome.com. Retrieved 1 May 2018.
  20. ^ Pigott, E.; Mandik-Nayak, L. (2012). "Addition of an indoleamine 2,3,-dioxygenase inhibitor to B cell-depletion therapy blocks autoreactive B cell activation and recurrence of arthritis in K/BxN mice". Arthritis and Rheumatism. 64 (7): 2169–2178. doi:10.1002/art.34406. PMC 3351581. PMID 22294267.

External links edit

39°59′20″N 75°15′22″W / 39.98882°N 75.25613°W / 39.98882; -75.25613

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