The division was initially known as North-West West 1 when it was created in 1987, and had a number of different names since with South Lancs/Cheshire 1 being the longest running. The division switched to its current name for the 2018–19 season due to the restructuring of the northern leagues by the RFU as a result of 19 Lancashire clubs withdrawing from RFU competitions across the leagues to form their own competitions. This would see the North Lancashire/Cumbria division abolished, with Lancashire-based sides from that league being transferred into Lancs/Cheshire 1, while the Cumbria sides were transferred into Cumbria 1.
The introduction of North 2 West for the 2019–20 season at tier 7 of the north west leagues, meant that Lancs/Cheshire Division 1 dropped down to being a tier 8 league.
The after the cancellation of Adult Competitive Leagues (National League 1 and below) for the 2020/21 season  that due to the coronavirus pandemic the league was disbanded with teams transferred into the Lancashire Merit Table competitions or ADM Lancashire leagues.
Restructuring of north-west leagues saw North-West West 1 renamed as Cheshire/Lancs South for the 1993–94 season. Promotion continued to be up to North West 2, while relegation was to either Cheshire or Lancashire South (new regional divisions of what was North-West West 2). The division was initially at tier 9 but the creation of National 5 North for the 1993–94 season meant that Cheshire/Lancs South dropped to become a tier 10 league.
The league system was restructured from top to bottom by the Rugby Football Union for the start of the 1996–97 season. Firstly, as part of the reorganisation of the Cheshire and Lancashire leagues, Cheshire/Lancs South was renamed South Lancs/Cheshire 1. The cancellation of National 5 North and creation of North West 3 meant that South/Lancs Cheshire 1 remained a tier 10 league, with promotion to North West 3 and relegation to the newly named South/Lancs Cheshire 2 - now back to being a single division. From the 1998–99 season onward the league was known as EuroManx South Lancs/Cheshire 1 after its sponsor EuroManx.
South Lancs/Cheshire 1 was renamed as Lancs/Cheshire 1 for the 2018–19 season continuing as a tier 7 league with promotion to North 1 West. The creation of North 2 West for the 2019–20 season meant that Lancs/Cheshire 1 dropped to being a tier 8 league with promotion into this new division. Relegation continued to Lancs/Cheshire 2 (formerly South Lancs/Cheshire 2).
For the 2018–19 season there was play-off between the runners-up of Lancashire/Cheshire 1 and Cumbria 1 and for the third and final promotion place to North 1 West. Previously Lancs/Cheshire sides had faced teams from North Lancashire/Cumbria (see following subsection). As of 2019–20 Lancashire/Cheshire 1 sides have one win to Cumbria's zero; and the home side has one win to the away side's zero. The introduction of North 2 West for the 2019–20 and the subsequent demotion of both Lancashire/Cheshire 1 and Cumbria 1 to tier 8 divisions, means that if the playoff continues it will be in place in the newly introduced division.
Cumbria 1 v Lancs/Cheshire 1 promotion play-off results
Between the 2000–01 and 2017–18 seasons there was a play-off between the runners-up of North Lancashire/Cumbria and South Lancs/Cheshire 1 for the third and final promotion place to North 1 West. The team with the superior league record had home advantage in the tie. This continued until the North Lancashire/Cumbria division was abolished due to RFU restructuring of the leagues. At the end of the 2017–18 season the North Lancashire/Cumbria and South Lancs/Cheshire 1 team sides had nine wins apiece; and the home team had won promotion on thirteen occasions compared to the away teams five.
North Lancashire/Cumbria v South Lancs/Cheshire 1 promotion play-off results
^The restructure of the North-West leagues for the following season with North-West West 3 being discontinued and North-West West 2 splitting into two regional leagues - Cheshire and Lancashire South - meant that there was no relegation, although bottom side Old Intonians would merge with Old Rockferrians to form Prenton RUFC and would enter the Cheshire league for the 1992–93 season.
^Reorganisation of the Lancashire and Cheshire leagues for the 1996–97 season meant that four teams instead of three were relegated into the new look South/Lancs Cheshire 2 - now back to being a single division.
^No relegation as division due to increase from 11 to 14 teams for the following season.