Open main menu

Lanatoside C (or isolanid) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally[1] or by the intravenous route.[2] It is marketed in a number of countries and is also available in generic form.[3] Its main indications are rapid response atrial fibrilation and paroxysmal supraventricular tachycardia,[citation needed] two common types of arrhythmia.

Lanatoside C
Lanatoside C.svg
Clinical data
Synonyms[6-[6-[6-[[12,14-dihydroxy- 10,13-dimethyl- 17-(5-oxo-2H-furan-3-yl)- 1,2,3,4,5,6,7,8,9,11,12,15,16,17- tetradecahydrocyclopenta[a]phenanthren- 3-yl]oxy]- 4-hydroxy- 2-methyloxan- 3-yl]oxy- 4-hydroxy- 2-methyloxan-3-yl]oxy- 2-methyl- 3-[3,4,5-trihydroxy- 6-(hydroxymethyl)oxan-2-yl]oxyoxan- 4-yl] acetate
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral, intravenous
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.037.754 Edit this at Wikidata
Chemical and physical data
FormulaC49H76O20
Molar mass985.116 g/mol g·mol−1
3D model (JSmol)
  (verify)

It is found in Digitalis lanata.[4]

ChemistryEdit

The substance is composed of four monosaccharides (glucose, 3-acetyldigitoxose and two digitoxoses) and an aglycon named digoxigenin.[5]

ReferencesEdit

  1. ^ Lypka, A.; Lazowski, J. (1979). "(title in Polish)" [Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration]. Wiadomości Lekarskie (in Polish). Warsaw, Poland. 32 (18): 1277–1281. PMID 506267.
  2. ^ Tàmmaro, A. E.; Baldoli, C. (1967). "On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects" [On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects]. La Clinica Terapeutica (in Italian). 40 (2): 157–161. PMID 5600177.
  3. ^ "Lanatoside C". International Drug Names. Drugs.com.
  4. ^ Determination of Lanatoside C and Digoxin in Digitalis lanata by Hplc and Its Application to Analysis of the Fermented Leaf Powder. Yukari Ikeda, Youichi Fujii and Mitsuru Yamazaki, J. Nat. Prod., 1992, volume 55, issue 6, pages 748–752, doi:10.1021/np50084a007
  5. ^ Desai, U. R. (2005). "Cardiac Glycosides". VCU School of Pharmacy.