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Lipase member H is an enzyme that in humans is encoded by the LIPH gene.[5][6][7]

LIPH
Identifiers
AliasesLIPH, AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1, lipase H
External IDsOMIM: 607365 MGI: 2388029 HomoloGene: 71802 GeneCards: LIPH
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for LIPH
Genomic location for LIPH
Band3q27.2Start185,506,262 bp[1]
End185,552,588 bp[1]
RNA expression pattern
PBB GE LIPH gnf1h05671 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139248

NM_001083894
NM_001289581
NM_001289582
NM_153404

RefSeq (protein)

NP_640341

NP_001077363
NP_001276510
NP_001276511
NP_700453

Location (UCSC)Chr 3: 185.51 – 185.55 MbChr 16: 21.95 – 22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.[7]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163898 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044626 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (Sep 2002). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine". Genomics. 80 (3): 268–73. doi:10.1006/geno.2002.6837. PMID 12213196.
  6. ^ Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H (Sep 2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid". J Biol Chem. 277 (37): 34254–63. doi:10.1074/jbc.M201659200. PMID 12063250.
  7. ^ a b "Entrez Gene: LIPH lipase, member H".

Further readingEdit