The building was first built in 1925 on the corner of Fifth and Walnut streets as the Kentucky Hotel. It was the last hotel built in Downtown Louisville before World War Two. The late 1960s experienced a large growth in new apartment construction throughout the United States. At the same time, some buildings were converted into apartment buildings, and in 1972 the Kentucky Hotel was converted to an apartment building and renamed the Kentucky Towers. In 1978, the Louisville Board of Aldermen voted 6–5 to rename Walnut Street to Muhammad Ali Boulevard. In 1997, Kentucky Towers was the largest residential building in Downtown Louisville.
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- Hill, Bob (November 19, 2005). "Ali stirs conflicting emotions in hometown". The Courier-Journal. Retrieved December 22, 2006.
- Nold, Chip; Bahr, Bob (1997). Insiders' Guide to Louisville, Kentucky & Southern Indiana, 2nd. Globe Pequot. p. 278. ISBN 978-1-57380-043-3.
- Jeffords, Sarah (June 22, 2007). "Kentucky Towers undergoing $3.5 million in renovations; Occupancy is up sharply under new management". Business First of Louisville. Retrieved September 29, 2010.
- Elson, Martha (September 7, 2010). "Company transforming Cherokee Triangle site into corporate headquarters". The Courier-Journal. Retrieved January 8, 2016. (subscription required)
- Siemionow, Maria (2009). Face to Face: My Quest to Perform the First Full Face Transplant. Kaplan Publishing. p. 104. ISBN 978-1-60714-051-1.
- Kentucky Towers -- Website