Karl Albert Hasselbalch

Karl Albert Hasselbalch (Danish pronunciation: [ˈkʰɑˀl ˈælˀpɐt ˈhæsl̩ˌpælˀk]; 1 November 1874 – 19 September 1962) was a Danish physician and chemist known for his work on the Henderson–Hasselbalch equation.

Karl Albert Hasselbalch
Karl Albert Hasselbalch

(1874-11-01)1 November 1874
Åstrup, Denmark
Died19 September 1962(1962-09-19) (aged 87)
Known forHenderson–Hasselbalch equation

Early life and educationEdit

Hasselbalch was born in Åstrup, near Hjørring, Denmark on 1 November 1874. Hasselbalch received his medical degree in 1898 and his doctorate in 1899 for his thesis on the respiratory metabolism in the chicken embryo.[1][2]


Hasselbalch was a pioneer in the use of pH measurement in medicine (with Christian Bohr, father of Niels Bohr), and he described how the affinity of blood for oxygen was dependent on the concentration of carbon dioxide. He was also first to determine the pH of blood. In 1916, he converted the 1908 equation of Lawrence Joseph Henderson to logarithmic form, which is now known as the Henderson–Hasselbalch equation.


  1. ^ Hasselbalch, Karl Albert: "Om Hønsefostrets Respiratoriske Stofskifte", Copenhagen, 1899.
  2. ^ "Karl Hasselbalch". Dansk Biografisk Leksikon (in Danish). Retrieved 21 January 2019.