Kaolin clotting time
Kaolin clotting time (KCT) is a sensitive test to detect lupus anticoagulants. There is evidence that suggests it is the most sensitive test for detecting lupus anticoagulants. It can also detect factor VIII inhibitors but is sensitive to unfractionated heparin as well.
|Kaolin clotting time|
|Test of||Blood plasma|
KCT was first described by Dr. Margolis in 1958.
KCT is similar to the activated partial thromboplastin time test, except it does not use exogenous phospholipid. Thus, a confirmatory test that uses excess phospholipid is needed to validate the presence of lupus anticoagulants.
Kaolin is the surface activator, and the test also requires small amounts of cell fragments and plasma lipids to provide the phospholipid surface required for coagulation. Therefore, the sample quality is important for the validity of the test.
If the KCT is less than 60 seconds, this suggests that the normal control plasma is contaminated with platelet fragments; therefore, the test is not valid.
- Gronowski, Ann M. (2004). Handbook of Clinical Laboratory Testing During Pregnancy. Springer Science & Business Media. p. 308. ISBN 9781592597871.
- Radhakrishnan, Kottayam (2013). Kaolin Clotting Time. Methods in Molecular Biology. 992. pp. 335–339. doi:10.1007/978-1-62703-339-8_25. ISBN 978-1-62703-338-1. PMID 23546725.
- Exner, T; Triplett, D. A.; Taberner, D. A.; Howard, M. A.; Harris, E. N. (1990). "Comparison of test methods for the lupus anticoagulant: International survey on lupus anticoagulants-I (ISLA-1)". Thrombosis and Haemostasis. 64 (3): 478–84. PMID 2128977.
- "Kaolin Clotting Time [KCT]". Retrieved 26 November 2014.
- Margolis, J (1958). "The kaolin clotting time; a rapid one-stage method for diagnosis of coagulation defects". Journal of Clinical Pathology. 11 (5): 406–9. PMC 479806. PMID 13575555.
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