Kahweol is a diterpenoid molecule found in the beans of Coffea arabica. It is structurally related to cafestol. It gets its name from the Arabic word "Ka-ah-wa", from which "coffee" derives. In French, it's evolved into the slang word "kawa", to designate coffee.
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||314.425 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Recent research suggests that kahweol may have beneficial effects on bone by inhibiting osteoclast differentiation. Another recent study confirmed that kahweol has anti-inflammatory and anti-angiogenic effects, offering a possible mechanism for the association found in epidemiological studies between consumption of unfiltered coffee and decreased risk of cancer.
- Fumimoto R, Sakai E, Yamaguchi Y, Sakamoto H, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T (Mar 2012). "The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation". J Pharmacol Sci. 118 (4): 479–86. doi:10.1254/jphs.11212FP. PMID 22447306.CS1 maint: uses authors parameter (link)
- Cárdenas C, Quesada AR, Medina MA (Aug 2011). "Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene". PLoS ONE. 6 (8): e23407. doi:10.1371/JOURNAL.PONE.0023407. PMC 3153489. PMID 21858104.CS1 maint: uses authors parameter (link)