KIF17

KIF17
Identifiers
Aliases	KIF17, Kif17, 5930435E01Rik, AW492270, Kif17b, mKIAA1405, KIF3X, KLP-2, OSM-3, kinesin family member 17
External IDs	OMIM: 605037 MGI: 1098229 HomoloGene: 5883 GeneCards: KIF17
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,718,017 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,029,278 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; spleen; ; prefrontal cortex; ; Brodmann area 9; ; right uterine tube; ; cingulate gyrus; ; nucleus accumbens; ; right lung; ; caudate nucleus; ; putamen;
	Top expressed in
	seminiferous tubule; ; secondary oocyte; ; spermatid; ; superior frontal gyrus; ; visual cortex; ; nucleus accumbens; ; spermatocyte; ; suprachiasmatic nucleus; ; cerebellar cortex; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; microtubule motor activity; microtubule binding; plus-end-directed microtubule motor activity; ATP binding; ATPase activity;
Cellular component	intraciliary transport particle B; cytoplasm; ciliary basal body; cytosol; kinesin complex; microtubule cytoskeleton; photoreceptor connecting cilium; periciliary membrane compartment; axoneme; microtubule; cytoskeleton; cell projection; cilium; dendrite cytoplasm; neuron projection;
Biological process	microtubule-based movement; cell projection organization; microtubule-based process; protein transport; protein-containing complex localization; vesicle-mediated transport; neurogenesis; intraciliary transport involved in cilium assembly; anterograde dendritic transport of neurotransmitter receptor complex;
	Sources:Amigo / QuickGO
Orthologs
	57576
	16559
	ENSG00000117245
	ENSMUSG00000028758
	Q9P2E2
	Q99PW8
	NM_001122819; NM_001287212; NM_020816
	NM_001190978; NM_010623
	NP_001116291; NP_001274141; NP_065867
	NP_001177907; NP_034753
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene.^[5]^[6] KIF17 and its close relative, C. elegans OSM-3,^[7] are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins.^[8] In contrast to heterotrimeric kinesin-2 motors,^[9] however, KIF17 and OSM-3 form distinct homodimeric complexes.^[10] Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane,^[5] whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.^[11]^[12]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117245 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028758 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Setou M, Nakagawa T, Seog DH, Hirokawa N (Jun 2000). "Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport". Science. 288 (5472): 1796–802. Bibcode:2000Sci...288.1796S. doi:10.1126/science.288.5472.1796. PMID 10846156.
^ "Entrez Gene: KIF17 kinesin family member 17".
^ Shakir MA, Fukushige T, Yasuda H, Miwa J, Siddiqui SS (July 1993). "C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein". NeuroReport. 4 (7): 891–4. doi:10.1097/00001756-199307000-00013. PMID 7690265.
^ Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L (October 2004). "A standardized kinesin nomenclature". J. Cell Biol. 167 (1): 19–22. doi:10.1083/jcb.200408113. PMC 2041940. PMID 15479732.
^ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70. Bibcode:1993Natur.366..268C. doi:10.1038/366268a0. PMID 8232586. S2CID 4367715.
^ Signor D, Wedaman KP, Rose LS, Scholey JM (February 1999). "Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis elegans". Mol. Biol. Cell. 10 (2): 345–60. doi:10.1091/mbc.10.2.345. PMC 25173. PMID 9950681.
^ Snow JJ, Ou G, Gunnarson AL, Walker MR, Zhou HM, Brust-Mascher I, Scholey JM (November 2004). "Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons". Nat. Cell Biol. 6 (11): 1109–13. doi:10.1038/ncb1186. PMID 15489852. S2CID 22416282.
^ Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ (July 2010). "Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP". Nat. Cell Biol. 12 (7): 703–10. doi:10.1038/ncb2073. PMC 2896429. PMID 20526328.

Further reading edit

Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Macho B, Brancorsini S, Fimia GM, Setou M, Hirokawa N, Sassone-Corsi P (December 2002). "CREM-dependent transcription in male germ cells controlled by a kinesin". Science. 298 (5602): 2388–90. Bibcode:2002Sci...298.2388M. doi:10.1126/science.1077265. PMID 12493914. S2CID 42448155.
Guillaud L, Setou M, Hirokawa N (January 2003). "KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons". J. Neurosci. 23 (1): 131–40. doi:10.1523/JNEUROSCI.23-01-00131.2003. PMC 6742138. PMID 12514209.
Chennathukuzhi V, Morales CR, El-Alfy M, Hecht NB (December 2003). "The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15566–71. Bibcode:2003PNAS..10015566C. doi:10.1073/pnas.2536695100. PMC 307608. PMID 14673085.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117245 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028758 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10846156-5] Setou M, Nakagawa T, Seog DH, Hirokawa N (Jun 2000). "Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport". Science. 288 (5472): 1796–802. Bibcode:2000Sci...288.1796S. doi:10.1126/science.288.5472.1796. PMID 10846156.

[entrez-6] "Entrez Gene: KIF17 kinesin family member 17".

[pmid7690265-7] Shakir MA, Fukushige T, Yasuda H, Miwa J, Siddiqui SS (July 1993). "C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein". NeuroReport. 4 (7): 891–4. doi:10.1097/00001756-199307000-00013. PMID 7690265.

[pmid15479732-8] Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L (October 2004). "A standardized kinesin nomenclature". J. Cell Biol. 167 (1): 19–22. doi:10.1083/jcb.200408113. PMC 2041940. PMID 15479732.

[pmid8232586-9] Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70. Bibcode:1993Natur.366..268C. doi:10.1038/366268a0. PMID 8232586. S2CID 4367715.

[pmid9950681-10] Signor D, Wedaman KP, Rose LS, Scholey JM (February 1999). "Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis elegans". Mol. Biol. Cell. 10 (2): 345–60. doi:10.1091/mbc.10.2.345. PMC 25173. PMID 9950681.

[pmid15489852-11] Snow JJ, Ou G, Gunnarson AL, Walker MR, Zhou HM, Brust-Mascher I, Scholey JM (November 2004). "Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons". Nat. Cell Biol. 6 (11): 1109–13. doi:10.1038/ncb1186. PMID 15489852. S2CID 22416282.

[pmid20526328-12] Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ (July 2010). "Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP". Nat. Cell Biol. 12 (7): 703–10. doi:10.1038/ncb2073. PMC 2896429. PMID 20526328.

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