|Lady consort of Monaco|
|Spouse||Honoré I, Lord of Monaco|
|Issue||Charles II, Lord of Monaco |
François of Monaco
Horace of Monaco
Hercules, Lord of Monaco
|Father||Giovanni Battista Grimaldi, Lord of Montaudion|
Isabella was the daughter of Giovanni Battista Grimaldi, Lord of Montaudion, and Maddalena Pallavicini. She was the niece of Etienne (Stephen) Grimaldi (d. 1561), who was the regent of Honoré I during his minority (1532-1540) and continued to be the de facto ruler of Monaco until his death, and the marriage between Isabella and Honoré I was arranged by Etienne. The marriage took place in 1545. She was widowed in 1581.
- Saige, Gustave (1897). Monaco: Ses Origines et Son Histoire. Imprimerie de Monaco. Retrieved 8 April 2019.