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Different bevels on hypodermic needles
Syringe on left, hypodermic needle with attached colour coded Luer-Lok connector on right
Hypodermic needle features

A hypodermic needle (from Greek ὑπο- (under-), and δέρμα (skin)), one of a category of medical tools which enter the skin, called sharps,[1] is a very thin, hollow tube with a sharp tip that contains a small opening at the pointed end. It is commonly used with a syringe, a hand-operated device with a plunger, to inject substances into the body (e.g., saline solution, solutions containing various drugs or liquid medicines) or extract fluids from the body (e.g., blood). They are used to take liquid samples from the body, for example taking blood from a vein in venipuncture. Large bore hypodermic intervention is especially useful in catastrophic blood loss or treating shock.

A hypodermic needle is used for rapid delivery of liquids, or when the injected substance cannot be ingested, either because it would not be absorbed (as with insulin), or because it would harm the liver. There are many possible routes for an injection, with the arm being a common location.

The hypodermic needle also serves an important role in research environments where sterile conditions are required. The hypodermic needle significantly reduces contamination during inoculation of a sterile substrate. The hypodermic needle reduces contamination for two reasons: First, its surface is extremely smooth, which prevents airborne pathogens from becoming trapped between irregularities on the needle's surface, which would subsequently be transferred into the media (e.g. agar) as contaminants; second, the needle's surface is extremely sharp, which significantly reduces the diameter of the hole remaining after puncturing the membrane and consequently prevents microbes larger than this hole from contaminating the substrate.[2][3][4][5]



Early use and experimentationEdit

The ancient Greeks and Romans knew injection as a method of medicinal delivery from observations of snakebites and poisoned weapons.[6] There are also references to "anointing" and "inunction" in the Old Testament as well as the works of Homer, but injection as a legitimate medical tool was not truly explored until the 17th century.[7]Christopher Wren performed the earliest confirmed experiments with crude hypodermic needles, performing intravenous injection into dogs in 1656.[7] These experiments consisted of using animal bladders (as the syringe) and goose quills (as the needle) to administer drugs such as opium intravenously to dogs. Wren and others' main interest was to learn if medicines traditionally administered orally would be effective intravenously. In the 1660s, J. D. Major of Kiel and J. S. Elsholtz of Berlin were the first to experiment with injections in humans.[6][8] These early experiments were generally ineffective and in some cases fatal. Injection fell out of favor for two centuries.

19th century developmentEdit

The 19th century saw the development of medicines that were effective in small doses, such as opiates and strychnine. This spurred a renewed interest in direct, controlled application of medicine. "Some controversy surrounds the question of priority in hypodermic medication."[9] Dr. Francis Rynd is generally credited with the first successful injection in 1844.[10][11] Dr. Alexander Wood’s main contribution was the all-glass syringe in 1851, which allowed the user to estimate dosage based on the levels of liquid observed through the glass.[12] Wood used hypodermic needles and syringes primarily for the application of localized, subcutaneous injection (localized anesthesia) and therefore was not as interested in precise dosages.[8] Simultaneous to Wood's work in Edinburgh, Dr. Charles Pravaz of Lyon also experimented with sub-dermal injections in sheep using a syringe of his own design. Pravaz designed a syringe measuring 3 cm (1.18 in) long and 5 mm (0.2 in) in diameter; it was made entirely of silver.[13]Dr. Charles Hunter, a London surgeon, is credited with the coining of the term "hypodermic" to describe subcutaneous injection in 1858. The name originates from two Greek words: hypo, "under", and derma, "skin". Furthermore, Hunter is credited with acknowledging the systemic effects of injection after noticing that a patient's pain was alleviated regardless of the injection’s proximity to the pained area.[7][8] Hunter and Wood were involved in lengthy legal disputes over not only the origin of the modern hypodermic needle, but also because of their disagreement to the medicine's effect once administered.

Modern improvementsEdit

Dr. Wood can be largely credited with the popularization and acceptance of injection as a medical technique, as well as the widespread use and acceptance of the hypodermic needle. The basic technology of the hypodermic needle has stayed largely unchanged since the 19th century, but as the years progressed and medical and chemical knowledge improved, small refinements have been made to increase safety and efficacy, with needles being designed and tailored for very particular uses. The trend of needle specification for use began in the 1920s, particularly for the administration of insulin to diabetics.[14] The onset of World War II spurred the early development of partially disposable syringes for the administration of morphine and penicillin on the battlefield. Development of the fully disposable hypodermic needle was spurred on in the 1950s for several reasons. The Korean War created blood shortages and in response disposable, sterile syringes were developed for collecting blood. The widespread immunization against polio during the period required the development of a fully disposable syringe system.[14][dead link]

The 1950s also saw the rise and recognition of cross-contamination from used needles. This led to the development of the first fully disposable plastic syringe by New Zealand pharmacist Colin Murdoch in 1956.[15] This period also marked a shift in interest from needle specifications to general sterility and safety. The 1980s saw the rise of the HIV epidemic and with it renewed concern over the safety of cross-contamination from used needles. New safety controls were designed on disposable needles to ensure the safety of medical workers in particular. These controls were implemented on the needles themselves, such as retractable needles, but also in the handling of used needles, particularly in the use of hard-surface disposal receptacles found in every medical office today.[14][dead link]. The modern two-piece hypodermic needle was invented by Manuel Jalón Corominas, a Spanish engineer in 1978.[16]


Hypodermic needles are normally made from a stainless-steel tube[17] through a process known as tube drawing where the tube is drawn through progressively smaller dies to make the needle. The needles are designed with the same general features, including a barrel, plunger, needle and cap. The end of the needle is bevelled to create a sharp pointed tip, letting the needle easily penetrate the skin.[18]


Six hypodermic needles on Luer connectors. These needles are normally used with other medical devices, such as a syringe; from top to bottom:
  • 26G × ​12″ (0.45 × 12 mm) (brown)
  • 25G × ​58″ (0.5 × 16 mm) (orange)
  • 22G × ​1 14″ (0.7 × 30 mm) (black)
  • 21G × ​1 12″ (0.8 × 40 mm) (green)
  • 20G × ​1 12″ (0.9 × 40 mm) (yellow)
  • 19G × ​1 12″ (1.1 × 40 mm) (cream)
See also Birmingham gauge.

The main system for measuring the diameter of a hypodermic needle is the Birmingham gauge (whereas French gauge is used mainly for catheters). Various needle lengths are available for any given gauge. Needles in common medical use range from 7 gauge (the largest) to 33 (the smallest). 21-gauge needles are most commonly used for drawing blood for testing purposes, and 16- or 17-gauge needles are most commonly used for blood donation, as the resulting lower pressure is less harmful to red blood cells (it also allows more blood to be collected in a shorter time).[19] Although reusable needles remain useful for some scientific applications, disposable needles are far more common in medicine. Disposable needles are embedded in a plastic or aluminium hub that attaches to the syringe barrel by means of a press-fit or twist-on fitting. These are sometimes referred to as "Luer Lock" connections, referring to the trademark Luer-Lok. The male and female luer lock and hub-- produced by pharmaceutical equipment manufacturers-- are two of the most critical parts of disposable hypodermic needles.[20]

Non-specialist useEdit

Hypodermic needles are usually used by medical professionals (dentists, phlebotomists, physicians, nurses, paramedics), but they are sometimes used by patients themselves. This is most common with type one diabetics, who may require several insulin injections a day.[21] It also occurs with patients who have asthma or other severe allergies. Such patients may need to take desensitization injections or they may need to carry injectable medicines to use for first aid in case of a severe allergic reaction. In the latter case, such patients often carry a syringe loaded with epinephrine (e.g. EpiPen),[22] diphenhydramine (e.g. Benadryl), or dexamethasone. Rapid injection of one of these drugs may stop a severe allergic reaction.

Multiple sclerosis patients may also treat themselves by injection; several MS therapies, including various interferon preparations, are designed to be self-administered by subcutaneous or intramuscular injection.[23] In some countries, erectile dysfunction patients may be prescribed Alprostadil in injectable form, which is self-injected directly into the base or side of the penis with a very fine hypodermic needle.

Hypodermic needles are also used by untrained users in recreational intravenous drug use (e.g., injecting solutions of heroin and water). Before governments attained current levels of awareness about the spread of disease through shared needles, hypodermic syringes in many countries were available only by prescription. Thus, in order to limit the spread of blood-borne diseases such as hepatitis and HIV through shared injection equipment, many countries have needle exchange programs in most larger cities. In some countries, such programs are wholly or partially subsidized by the government. Blunted needles, manufactured without a sharp bevel and usually non-sterile, are used industrially for filling small containers or accurately applying small amounts of solvent or glue.


It is estimated that anywhere from nearly 3.5 to 10% of the world’s population may have a phobia of needles (trypanophobia)[24], and it is much more common in children, ages 5–17. Patients can ask for a patch from the nurse to numb the area of where the injection will take place to reduce pain.[25] For children and teenagers various techniques may be effective at reducing distress or pain related to needles.[26] Techniques include: distraction, hypnosis, combined cognitive behaviour therapy, and breathing techniques.[26]

See alsoEdit


  1. ^ "Handling sharps and needles: MedlinePlus Medical Encyclopedia". Retrieved 4 April 2018.
  2. ^ Elsheikh, HA; Ali, BH; Homeida, AM; Lutfi, AA; Hapke, HJ (May–Jun 1992). "The effects of fascioliasis on the activities of some drug-metabolizing enzymes in desert sheep liver". The British veterinary journal. 148 (3): 249–57. doi:10.1016/0007-1935(92)90048-6. PMID 1617399.
  3. ^ Korenman, SG (September 1975). "Estrogen receptor assay in human breast cancer". Journal of the National Cancer Institute. 55 (3): 543–5. doi:10.1093/jnci/55.3.543. PMID 169381.
  4. ^ Scott, Gene E.; Zummo, Natale (1 January 1988). "Sources of Resistance in Maize to Kernel Infection by Aspergillus flavus in the Field". Crop Science. 28 (3): 504. doi:10.2135/cropsci1988.0011183X002800030016x.
  5. ^ "Experimental Infection of Host Grasses and Sedges with Atkinsonella hypoxylon and Balansia cyperi (Balansiae, Clavicipitaceae)". Mycologia. 80 (3): 291–297. 1988. doi:10.2307/3807624. JSTOR 3807624.
  6. ^ a b Norn S, Kruse PR, Kruse E (2006). "On the history of injection". Dan Medicinhist Arbog. 34: 104–1.
  7. ^ a b c Kotwal, Atul. "Innovation, diffusion and safety of a medical technology: a review of the literature on injection practice". Social Science & Medicine Volume 60, Issue 5, March 2005, pp. 1133–1147
  8. ^ a b c Ball C (Jun 2006). "The early development of intravenous apparatus". Anaesth Intensive Care. 34 (Suppl 1): 22–6.
  9. ^ Logan Clendening, Source Book of Medical History, p. 419 (1960)
  10. ^ Walter Reginald Bett, The History and Conquest of Common Diseases p. 145 (1954)
  11. ^ "The Irish doctor who invented the syringe". Retrieved 4 April 2018.
  12. ^ Kotwal, Atul. "Innovation, diffusion and safety of a medical technology: a review of the literature on injection practices". Social Science & Medicine Volume 60, Issue 5, March 2005, pp. 1133–1147
  13. ^ Syringe,
  14. ^ a b c Beckton Dickinson and Company, "Four Major Phases of Injection Device Development", Syringe and Needle History Archived May 8, 2015, at the Wayback Machine.
  15. ^ "Hypodermic syringe". Retrieved 4 April 2018.
  16. ^ "The Disposable Syringe". Retrieved 2018-12-13.
  17. ^ How do they get the hole through a hypodermic needle? at The Straight Dope.
  18. ^ "How syringe is made - material, production process, manufacture, making, history, used, processing, parts". How Products Are Made. Retrieved 2018-01-03.
  19. ^ Blood Transfusions and Angio Size? Archived 2016-03-03 at the Wayback Machine.
  20. ^ "Medical Industry Cycle Times | Davenport Machine". Davenport Machine. Retrieved 2018-01-03.
  21. ^ "Giving an Insulin Injection". Retrieved 2010-08-19.
  22. ^ "How to Stop Allergic Reactions". EpiPen. Retrieved 2010-08-19.
  23. ^ "Multiple Sclerosis Treatments". 2008-01-21. Retrieved 2013-01-13.
  24. ^ "Fear of Needles Phobia – Trypanophobia". Retrieved 2018-01-03.
  25. ^ "The Needle Phobia Page". Retrieved 2010-08-19.
  26. ^ a b Birnie, Kathryn A.; Noel, Melanie; Chambers, Christine T.; Uman, Lindsay S.; Parker, Jennifer A. (2018-10-04). "Psychological interventions for needle-related procedural pain and distress in children and adolescents". The Cochrane Database of Systematic Reviews. 10: CD005179. doi:10.1002/14651858.CD005179.pub4. ISSN 1469-493X. PMID 30284240.

External linksEdit