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The human nose is the most protruding part of the face. It bears the nostrils and is the first organ of the respiratory system. It is also the principal organ in the olfactory system. The shape of the nose is determined by the nasal bones and the nasal cartilages, including the nasal septum which separates the nostrils and divides the nasal cavity into two. On average the nose of a male is larger than that of a female.
Front view of human nose
Cross-section of the interior of a nose also showing olfactory components
|Artery||sphenopalatine artery, greater palatine artery|
|Nerve||external nasal nerve|
The main function of the nose is respiration, and the nasal mucosa lining the nasal cavity and the paranasal sinuses carries out the necessary conditioning of inhaled air by warming and moistening it. Nasal conchae, shell-like bones in the walls of the cavities, play a major part in this process. Filtering of the air by nasal hair in the nostrils prevents large particles from entering the lungs. Sneezing is a reflex to expel unwanted particles from the nose that irritate the mucosal lining. Sneezing can transmit infections, because aerosols are created in which the droplets can harbour pathogens.
There are many plastic surgery procedures on the nose, known as rhinoplasties available to correct various structural defects or to change the shape of the nose. Defects may be congenital, result from nasal disorders or from trauma and these are carried out by reconstructive surgery. Procedures used to change a nose shape electively are carried out by cosmetic surgeries.
- 1 Structure
- 2 Blood supply and drainage
- 3 Nerve supply
- 4 Development
- 5 Function
- 6 Clinical significance
- 7 Society and culture
- 8 Evolutionary hypotheses
- 9 Neoteny
- 10 See also
- 11 References
- 12 External links
Several bones and nasal cartilages make up the bony-cartilaginous framework of the nose, and the internal structure. The nose is also made up of types of soft tissue such as skin, epithelia, mucous membrane, muscles, nerves, and blood. In the skin there are sebaceous glands, and in the mucous membrane there are nasal glands.
The framework of the nose is made up of bone and cartilage which provides strong protection for the internal structures of the nose. The arrangement of the cartilages allows flexibility through muscle control to enable airflow to be modified.
The nasal part of the frontal bone lies between the brow ridges, and ends in a serrated nasal notch. The notch articulates at the front with the paired nasal bones, and at the sides with the small lacrimal bones, and with the frontal process of each maxilla. The nasal bones in the upper part of the nose are joined together by the midline internasal suture. They join with the septal cartilage at a junction known as the rhinion. The rhinion is the midpoint of the internasal suture at the join with the cartilage, and from the rhinion to the apex, or tip, the framework is of cartilage.
Above and to the back, the bony upper part of the nasal septum is made up of the perpendicular plate of the ethmoid bone, and the bony lower part is made up of the vomer bone that lies below. The floor of the nose is made up of the incisive bone and the horizontal plates of the palatine bones, and this makes up the hard palate of the roof of the mouth. The two horizontal plates join together at the midline and form the posterior nasal spine that gives attachment to the musculus uvulae in the uvula.
The internal roof of the nasal cavity is composed of the horizontal, perforated cribriform plate of the ethmoid bone through which pass sensory fibres of the olfactory nerve (CN1). Below and behind the cribriform plate, sloping down at an angle, is the face of the sphenoid bone.
The two maxilla bones join at the base of the nose at the lower nasal midline between the nostrils, and at the top of the philtrum to form the anterior nasal spine. This thin projection of bone holds the cartilaginous center of the nose. It is also an important cephalometric landmark.
The nasal cartilages are the septal, lateral, major alar, and minor alar cartilages. The major and minor cartilages are also known as the greater and lesser alar cartilages. There is a narrow strip of cartilage called the vomeronasal cartilage that lies between the vomer and the septal cartilage.
The septal nasal cartilage, extends from the nasal bones in the midline, to the bony part of the septum in the midline, posteriorly. It then passes along the floor of the nasal cavity. The septum is quadrangular–the upper half is attached to the two lateral nasal cartilages which are fused to the dorsal septum in the midline. The septum is laterally attached, with loose ligaments, to the bony margin of the anterior nasal aperture, while the inferior ends of the lateral cartilages are free (unattached). The three or four minor alar cartilages are adjacent to the lateral cartilages, held in the connective tissue membrane, that connects the lateral cartilages to the frontal process of the maxilla.
The major alar cartilages are thin, U-shaped plates of cartilage on each side of the nose that form the lateral and medial walls of the vestibule, known as the medial and lateral crura. The medial crura are attached to the septal cartilage, forming fleshy parts at the front of the nostrils on each side of the septum, called the medial crural footpods. The medial crura meet at the midline below the end of the septum to form the columella and infratip lobule. At the peaks of their folds they form the alar domes the tip-defining points of the nose. They then fold outwards, above and to the side of the nostrils forming the lateral crura. The major alar cartilages are freely moveable and can respond to muscles to either open or constrict the nostrils.
There is a reinforcing structure known as the nasal scroll that resists internal collapse from airflow pressure generated by normal breathing. This structure is formed by the junction between the lateral and major cartilages. Their edges interlock by one scrolling upwards and one scrolling inwards.
The nasal root is the top of the nose that attaches the nose to the forehead. The nasal root is above the bridge and below the glabella, forming an indentation known as the nasion at the frontonasal suture where the frontal bone meets the nasal bones.
The nasal ridge (nasal dorsum) is the border between the root and the tip of the nose which in profile can be variously shaped.
The ala of the nose (ala nasi, wing of the nose) is the lower lateral surface of the external nose, shaped by the alar cartilage and covered in dense connective tissue. The alae flare out to form a rounded eminence around the nostril.
The skin of the nose varies in thickness along its length. From the glabella to the bridge the skin is thick, fairly flexible, and mobile. It tapers to the bridge where it is thinnest and least flexible as it adheres to the bony framework. The rest of the skin of the lower nose is as thick as the top section and has more sebaceous glands. The glands produce sebum in a higher concentration than on other parts of the body.
The nasal cavity is the large internal space of the nose. The cavity is divided into two cavities known as fossae by the nasal septum, which separates the nostrils. Each fossa is the continuation of a nostril. The division into two fossae enables the functioning of the nasal cycle that slows down the air conditioning process.
Other nasal cavities are the four paired paranasal sinuses that drain into the nasal cavity. The nasal cavity, from the limen nasi in the vestibule, is lined with respiratory epithelium. This is a ciliated tissue with mucus-secreting goblet cells, that maintains the nasal moisture and protects the respiratory tract from infection and atmospheric particulates. Respiratory epithelium is also the lining of the paranasal sinuses.
On the lateral wall of each cavity are three shell-like bones called conchae, arranged as superior, middle and inferior nasal conchae. The conchae are also known as turbinates. Below each concha is a corresponding superior, middle, and inferior nasal meatus, or passage. Sometimes when the superior concha is narrow, a fourth supreme nasal concha is present situated above and sharing the space with the superior concha. The conchae extend along the length of the nasal cavity. 
Roof of cavityEdit
The internal roof of the nasal cavity is composed of the horizontal, perforated cribriform plate of the ethmoid bone through which pass sensory fibres of the olfactory nerve. There is an area of olfactory mucosa in the roof of the cavity. This region is about 5 square cm in each fossa covering the superior concha, the cribriform plate, and the nasal septum.
At the back of the nasal cavity there are two openings, one from each fossa, called choanae. The choanae are also called the posterior nostrils and give entrance to the nasopharynx and rest of the respiratory tract.
There is a nasal valve area in the cavity responsible for providing resistance to the flow of air. This enables an increased time for warming and moistening the air. This area is of two nasal valves. The internal nasal valve is the narrowest part of the airway in the middle third of the cavity. The larger external nasal valve is located in the alar wall.  The angle between the septum and the sidewall needs to be sufficient for unobstructed airflow.
The nasal vestibule is the frontmost part of the nasal cavity, and is enclosed by cartilages. The vestibule of the nose is lined with skin, hair follicles, and a large number of sebaceous glands. A mucous ridge known as the limen nasi separates the vestibule from the rest of the nasal cavity and marks the change from the skin of the vestibule to the respiratory epithelium of the rest of the nasal cavity. This area is also known as a mucocutaneous junction that has a dense microvasculature. 
Drainage into nasal cavityEdit
The respiratory epithelium that lines the sinuses is closely adhered to the membrane of the underlying bone. A narrow opening called a sinus ostium from each of the paranasal sinuses allows drainage into the nasal cavity. The maxillary sinus is the largest of the sinuses and drains into the middle meatus. Adults have a high concentration of cilia in the ostia. The increased cilia and the narrowness of the sinus openings allow for an increased time for moisturising, and warming. The cilia in the sinuses beat towards the openings into the nasal cavity. Most of the ostia open into the middle meatus and the anterior ethmoid, that together are termed the ostiomeatal complex.
The shape of the nose varies widely due to differences in the nasal bone shapes and formation of the bridge of the nose. Some nose shapes were classified for surgeries by Eden Warwick in Nasology 1848:
Class I. The aquiline nose.
Other terms are used to describe the shape of the nose, and can also include a reference to the nasal index used to classify ethnicity: Leptorrhine describes a long, narrow nose. Hyperleptorrhine is a very long, narrow nose with a nasal index of 40 to 55. Platyrrhine is a short, broad nose. Paul Topinard developed the nasal index for studies in India. The nasal index is the ratio of the width of the nose to the nasal height. Some of the types used in Nasology are also used by Topinard. He took narrow shapes as in 1-5 to be European; medium width shape 6 were "yellow races"; broad nose shape 7 were African, and broad nose shape 8 were taken to be Melanesian and Australian Aboriginal.
Some deformities of the nose are named, such as the pug nose and the saddle nose. The pug nose is characterised by excess tissue from the apex that is out of proportion to the rest of the nose. A low and underdeveloped nasal bridge may also be evident. A saddle nose is mostly associated with trauma to the nose but can be caused by other conditions such as cocaine abuse and leprosy.
Some birth defects such as Down syndrome commonly present a small nose with a flattened nasal bridge. This can be due to the absence of one or both nasal bones, shortened nasal bones, or nasal bones that have not fused in the midline.
The movements of the nose are controlled by groups of facial and neck muscles that are set deep to the skin. There are four interconnected groups connected by the superficial fascia that covers, invests and forms the terminations of the muscles.
The compressor muscle group includes the transverse nasalis muscle.
The dilator muscle group includes the dilator naris muscle that expands the nostrils; it is in two parts: (i) the dilator naris anterior muscle, and (ii) the dilator naris posterior muscle.
Blood supply and drainageEdit
- Internal carotid
The main branches from the interior carotid are the anterior ethmoidal artery, and the posterior ethmoidal artery that supplies the septum, and these derive from the ophthalmic artery. One of the terminal branches of the ophthalmic artery is the dorsal nasal artery which divides into two branches. One branch crosses the root of the nose and joins with the angular artery, and the other branch joins with the lateral nasal branch of facial artery which supplies the nasal ridge and alae.
- External carotid
The lateral walls of the nasal cavity and the septum are supplied by the sphenopalatine artery, and by the anterior and posterior ethmoid arteries. There is additional supply from the superior labial artery and the greater palatine artery.
The nasal ridge is supplied by branches of the internal maxillary artery (infraorbital) and the ophthalmic arteries from the common carotid artery system.
Veins of the nose include the angular vein that drains the side of the nose, receiving lateral nasal veins from the alae. The angular vein joins with the superior labial vein. Some small veins from the nasal ridge (nasal dorsum) drain to the nasal arch of the frontal vein at the root of the nose.
In the posterior region of the cavity, specifically in the posterior part of the inferior meatus is a venous plexus known as Woodruff's plexus. This plexus is made up of large thin-walled veins with little soft tissue such as muscle or fiber. The mucosa of the plexus is thin with very few structures.
There are no lymph nodes in the face, except those in the parotid-buccal region. From different areas of the nose superficial lymphatic vessels run with the veins and deep lymphatic vessels travel with the arteries.
The nasal part of the lymphatic system arises from the superficial mucosa, and drains posteriorly to the retropharyngeal lymph nodes, and anteriorly to either the upper deep cervical lymph nodes (in the neck), or to the submandibular lymph nodes (in the lower jaw), or into both groups.
- The nasociliary nerve – conveys sensation to the skin area of the nose, and the mucous membrane of the nasal vestibule.
- The anterior ethmoidal nerve is a continuation of the nasociliary nerve and conveys sensation in the anterior half of the nasal cavity: (a) the internal areas of the ethmoid sinus and the frontal sinus; and (b) the external areas, from the nasal tip to the rhinion: the anterior tip of the terminal end of the nasal-bone suture.
- The posterior ethmoidal nerve – serves the upper half of the nasal cavity, the sphenoid and the ethmoid sinuses.
- Intratrochlear nerve – conveys sensation to the medial region of the eyelids, the palpebral conjunctiva, the nasion (nasolabial junction), and the bony dorsum.
- Maxillary nerve – conveys sensation to the upper jaw, the face and the nostrils.
- Internal nasal branches of infraorbital nerve – conveys sensation to the septum.
- Zygomatic nerve – through the zygomatic bone and the zygomatic arch, conveys sensation to the cheekbone areas.
- Sphenopalatine nerve – divides into the lateral branch and the septal branch, and conveys sensation from the rear and the central regions of the nasal cavity.
The supply of parasympathetic nerves to the face and the upper jaw (maxilla) derives from the greater superficial petrosal (GSP) branch of cranial nerve VII, the facial nerve. The GSP nerve joins the deep petrosal nerve (of the sympathetic nervous system), derived from the carotid plexus, to form the vidian nerve (in the vidian canal) that traverses the pterygopalatine ganglion (an autonomic ganglion of the maxillary nerve), wherein only the parasympathetic nerves form synapses, which serve the lacrimal gland and the glands of the nose and of the palate, via the (upper jaw) maxillary division of cranial nerve V, the trigeminal nerve.
Development of the noseEdit
In the early development of the embryo, neural crest cells migrate to form the mesenchymal tissue as ectomesenchyme of the pharyngeal arches. By the end of the fourth week, the first pair of pharyngeal arches form five facial prominences or processes - an unpaired frontonasal process, paired mandibular processes and paired maxillary processes. The nose is largely formed by the fusion of these five facial prominences. The frontonasal process gives rise to the bridge of the nose. The medial nasal processes provide the crest and the tip of the nose, and the lateral nasal processes form the alae or sides of the nose. The frontonasal process is a proliferation of mesenchyme in front of the brain vesicles. and makes up the upper border of the stomadeum.
During the fifth week the maxillary processes increase in size and at the same time the ectoderm of the frontonasal process becomes thickened at its sides and also increases in size, forming the nasal placodes. The nasal placodes are also known as the olfactory placodes. This development is induced by the ventral part of the forebrain. In the sixth week the ectoderm in each nasal placode invaginates to form an indented oval-shaped pit, which forms a surrounding raised ridge of tissue. Each nasal pit forms a division between the ridges, into a lateral nasal process on the outer edge, and a medial nasal process on the inner edge.
In the sixth week the nasal pits deepen as they penetrate into the underlying mesenchyme. At this time, the medial nasal processes migrate towards each other and fuse forming the primordium of the bridge of the nose and the septum. The migration is helped by the increased growth of the maxillary prominences medially, which compresses the medial nasal processes towards the midline. Their merging takes place at the surface, and also at a deeper level. The merge forms the intermaxillary segment, and this is continuous with the rostral part of the nasal septum. The tips of the maxillary processes also grow and fuse with the intermaxillary process. The intermaxillary process gives rise to the philtrum of the upper lip.
At the end of the sixth week the nasal pits have deepened further and they fuse to make a large ectodermal nasal sac. This sac will be above and to the back of the intermaxillary process. Leading into the seventh week, the nasal sac floor and posterior wall grow to form a thickened plate-like ectodermal structure called the nasal fin. The nasal fin separates the sac from the oral cavity. Within the fin, vacuoles develop that fuse with the nasal sac. This enlarges the nasal sac and at the same time thins the fin to a membrane - the oronasal membrane that separates the nasal pits from the oral cavity. During the seventh week the oronasal membrane ruptures and disintegrates to form an opening - the single primitive choana. The intermaxillary segment extends posteriorly to form the primary palate which makes up the floor of the nasal cavity. During the eighth and ninth weeks a pair of thin extensions form from the medial walls of the maxillary process. These extensions are called the palatine shelves that form the secondary palate. The secondary palate will endochondrally ossify to form the hard palate - the end-stage floor of the nasal cavity. During this time ectoderm and mesoderm of the frontonasal process produce the midline septum. The septum grows down from the roof of the nasal cavity and fuses with the developing palates along the midline. The septum divides the nasal cavity into two nasal passages opening into the pharynx through the definitive choanae.
At ten weeks, the cells differentiate into muscle, cartilage, and bone. Problems at this stage of development can cause birth defects such as choanal atresia (absent or closed passage), facial clefts and nasal dysplasia (faulty or incomplete development) or extremely rarely polyrrhinia the formation of a duplicate nose.
Development of the paranasal sinusesEdit
The four pairs of paranasal sinuses - the maxillary, ethmoid, sphenoid, and frontal, develop from the nasal cavity as invaginations extending into their named bones. Two pairs of sinuses form during prenatal development and two pairs form after birth. The maxillary sinuses are the first to appear during the fetal third month. They slowly expand within the maxillary bones and continue to expand throughout childhood. The maxillary sinuses form as invaginations from the nasal sac. The ethmoid sinuses appear in the fetal fifth month as invaginations of the middle meatus. The ethmoid sinuses do not grow into the ethmoid bone and do not completely develop until puberty.
The sphenoid sinuses are extensions of the ethmoid sinuses into the sphenoid bones. They appear in the fifth month of life and continue to enlarge during childhood. The frontal sinuses develop in the fifth or sixth year of childhood a of the middle meatus.nd continue expanding throughout adolescence. Each frontal sinus is made up of two independent spaces that develop from two different sources; one from the expansion of ethmoid sinuses into frontal bone, and the other develops from invagination. They never coalesce so drain independently.
The nose is the first organ of the upper respiratory tract in the respiratory system, and its main function is the supply and conditioning of inhaled air to the rest of the respiratory tract and the lungs. Another function is to filter the air by removing particulates. Nasal hair in the nostrils traps large particles preventing their entry into the lungs.
The three positioned nasal conchae in each cavity provide four grooves as air passages, along which the air is circulated and moved to the nasopharynx. The internal structures and cavities, including the conchae and paranasal sinuses form an integrated system for the conditioning (moistening and warming) and filtering of the air breathed in through the nose. This functioning also includes the major role of the nasal mucosa, and the resulting conditioning of the air before it reaches the lungs is important in maintaining the internal environment and proper functioning of the lungs. The turbulence created by the conchae and meatuses optimises the warming, moistening, and filtering of the mucosa. A major protective role is thereby provided by these structures of the upper respiratory tract, in the passage of air to the more delicate structures of the lower respiratory tract.
Sneezing is an important protective reflex initiated by irritation of the nasal mucosa to expel unwanted particles through the mouth and nose.  Photic sneezing is a reflex brought on by different stimuli such as bright lights.
The nose also plays the major part in the olfactory system. It contains an area of specialised cells, olfactory receptor neurons responsible for the sense of smell. Olfactory mucosa in the upper nasal cavity, contains a type of nasal gland called olfactory glands or Bowman's glands which help in olfaction. The nasal conchae also help in olfaction function, by directing air-flow to the olfactory region.
Normal speech is produced with pressure from the lungs. This can be modified using airflow through the nose in a process called nasalisation. This involves the lowering of the soft palate to produce nasal vowels and consonants by allowing air to escape from both the nose and the mouth. Nasal airflow is also used to produce a variety of nasal clicks called click consonants. The paranasal sinuses act as sound chambers in vocal resonation.
One of the most common medical conditions involving the nose is a nosebleed (epistaxis). Most nosebleeds occur in Kiesselbach's plexus, a vascular plexus in the lower front part of the septum involving the convergence of four arteries. A smaller proportion of nosebleeds that tend to be nontraumatic, occur in Woodruff's plexus. Woodruff's plexus is a venous plexus of large thin-walled veins lying in the posterior part of the inferior meatus.
Another common condition is nasal congestion, usually a symptom of infection, particularly sinusitis, or other inflammation of the nasal lining called rhinitis, including allergic rhinitis and nonallergic rhinitis. Chronic nasal obstruction resulting in breathing through the mouth can greatly impair or prevent the nostrils from flaring. One of the causes of snoring is nasal obstruction, and anti-snoring devices such as a nasal strip help to flare the nostrils and keep the airway open. Nasal flaring usually seen in children, happens when breathing is difficult. Most conditions of nasal congestion also cause a loss of the sense of smell (anosmia). This may also occur in other conditions, for example following trauma, in Kallmann syndrome or Parkinson's disease. A blocked sinus ostium, an opening from a paranasal sinus, will cause fluid to accumulate in the sinus.
Because of the special nature of the blood supply to the human nose and surrounding area, it is possible for retrograde infections from the nasal area to spread to the brain. For this reason, the area from the corners of the mouth to the bridge of the nose, including the nose and maxilla, is known as the danger triangle of the face.
Specific systemic diseases, infections or other conditions that may result in destruction of part of the nose (for example, the nasal bridge, or nasal septal perforation) are rhinophyma, skin cancer (for example, basal cell carcinoma), granulomatosis with polyangiitis, systemic lupus erythematosus, rheumatoid arthritis, tuberculosis, syphilis, leprosy and exposure to cocaine, chromium or toxins. The nose may be stimulated to grow in acromegaly, a condition caused by an excess of growth hormone.
A common anatomic variant is an air-filled cavity within a concha known as a concha bullosa. In rare cases a polyp can form inside a bullosa. Usually a concha bullosa is small and without symptoms but when large can cause obstruction to sinus drainage.
Some drugs can be nasally administered, and these include nasal sprays and topical treatments. The septal cartilage can be destroyed through the repeated inhalation of recreational drugs such as cocaine. This, in turn, can lead to more widespread collapse of the nasal skeleton.
Badly positioned alar cartilages lack proper support, and can affect the function of the external nasal valve. This can cause breathing problems particularly during deep inhalation. The surgical procedure to correct breathing problems due to disorders in the nasal structures is called a rhinoplasty, and this is also the procedure used for a cosmetic surgery when it is commonly called a "nose job". For surgical procedures of rhinoplasty, the nose is mapped out into a number of subunits and segments. This uses nine aesthetic nasal subunits and six aesthetic nasal segments. A septoplasty is the specific surgery to correct a nasal septum deviation.
Several nasal procedures of the nose and paranasal sinuses can be carried out using minimally-invasive nasal endoscopy. These procedures aim to restore sinus ventilation, mucociliary clearance, and maintain the health of the sinus mucosa.  Some non-nasal surgeries can also be carried out through the use of an endoscope that is entered through the nose. These endoscopic endonasal surgeries are used to remove tumours from the front of the base of the skull.
Society and cultureEdit
Some people choose to have cosmetic surgery called a rhinoplasty, to change the appearance of their nose. Nose piercings are also common, such as in the nostril, septum, or bridge. In certain Asian countries such as China, Japan, South Korea, Malaysia, Thailand and Bangladesh, rhinoplasties are commonly carried out to create a more developed nose bridge or a "high nose". Similarly, "DIY nose lifts" in the form of re-usable cosmetic items have become popular and are sold in many Asian countries such as China, Japan, South Korea, Taiwan, Sri Lanka and Thailand. A high-bridged nose has been a common beauty ideal in many Asian cultures dating back to the beauty ideals of ancient China and India.
Nose-picking is a common, mildly taboo habit. Medical risks include the spread of infections, nosebleeds and, rarely, perforation of the nasal septum. When it becomes compulsive it is termed rhinotillexomania. The wiping of the nose with the hand, commonly referred to as the "allergic salute", is also mildly taboo and can result in the spreading of infections as well. Habitual as well as fast or rough nose wiping may also result in a crease (known as a transverse nasal crease or groove) running across the nose, and can lead to permanent physical deformity observable in childhood and adulthood.
Clive Finlayson of the Gibraltar Museum said the large Neanderthal noses were an adaption to the cold, Todd C. Rae of the American Museum of Natural History said primate and arctic animal studies have shown sinus size reduction in areas of extreme cold rather than enlargement in accordance with Allen's rule. Therefore, Todd C. Rae concludes that the design of the large and prognathic Neanderthal nose was evolved for the hotter climate of the Middle East and Africa and remained unchanged when they entered Europe 
Miquel Hernández of the Department of Animal Biology at the University of Barcelona said the "high and narrow nose of Eskimos" and "Neanderthals" is an "adaption to a cold and dry environment", since it contributes to warming and moisturizing the air and the "recovery of heat and moisture from expired air".
Stephen Jay Gould has noted that larger noses are less neotenous, especially the large Grecian nose. Women have smaller noses than men due to not having increased secretion of testosterone in adolescence. Smaller noses, along with other neotenous features such as large eyes and full lips, are generally considered more attractive on women. Werner syndrome, a condition that causes the appearance of premature aging, causes a "bird-like" appearance due to pinching of the nose while, conversely, Down syndrome, a neotenizing condition, causes a flattening of the nose.
- Saladin, K (2011). Human anatomy (3rd ed.). McGraw-Hill. pp. 633–636. ISBN 9780071222075.
- Singh, Vishram (2014). Textbook of anatomy head, neck and brain. Volume 3 (Second ed.). Elsevier. pp. 251–263. ISBN 9788131237274.
- Knipe, Henry. "Anterior nasal spine fracture | Radiology Case | Radiopaedia.org". radiopaedia.org. Retrieved 24 October 2018.
- "Glossary: nasal spine (anterior)". ArchaeologyInfo.com. Archived from the original on 2017-03-01. Retrieved 2017-02-28.
- Dory, Miri (March 13, 2014). "Cephalometric analysis", Cephx.
- Lang, Johannes (1989). Clinical Anatomy of the Nose, Nasal Cavity and Paranasal Sinuses. Thieme. ISBN 9783137384014.
- "Vomeronasal cartilage".
- Schünke, Michael; Ross, Lawrence M.; Schulte, Erik; Lamperti, Edward D.; Schumacher, Udo (2007). Thieme Atlas of Anatomy: Head and Neuroanatomy. Thieme. ISBN 9781588904416.
- Bell, Daniel J. "Columella | Radiology Reference Article | Radiopaedia.org". Radiopaedia.
- Ballenger, John Jacob; Snow, James Byron (2003). Ballenger's Otorhinolaryngology: Head and Neck Surgery. PMPH-USA. ISBN 9781550091977. Retrieved 17 March 2019.
- Moore, Keith; Dalley, Arthur; Agur, Anne (2018). Clinically oriented anatomy (Eighth ed.). Wolters Kluwer. pp. 963–968. ISBN 9781496347213.
- Gubisch, Wolfgang (10 November 2017). Mastering Advanced Rhinoplasty. Springer. ISBN 9783319675374. Retrieved 17 March 2019.
- "Nasion definition and meaning | Collins English Dictionary". www.collinsdictionary.com. Retrieved 2019-11-06.
- Tortora, G; Anagnostakos, N (1987). Principles of anatomy and physiology (5th. Harper international ed.). Harper & Row. p. 556. ISBN 978-0063507296.
- "Archived copy". Archived from the original on 2007-11-30. Retrieved 2007-06-18.CS1 maint: archived copy as title (link)
- Thomas Hummel; Antje Welge-Lüssen (1 January 2006), Taste and Smell: An Update, Karger Medical and Scientific Publishers, pp. 12–, ISBN 978-3-8055-8123-3
- Wagenmann, M; Naclerio, RM (September 1992). "Anatomic and physiologic considerations in sinusitis". The Journal of Allergy and Clinical Immunology. 90 (3 Pt 2): 419–23. doi:10.1016/0091-6749(92)90161-T. PMID 1527330.
- "Paranasal Sinus Anatomy: Overview, Gross Anatomy, Microscopic Anatomy". 5 April 2018. Retrieved 10 November 2018. Cite journal requires
- Saladin, Kenneth (2012). Anatomy & physiology : the unity of form and function (6th ed.). McGraw-Hill. pp. 593–595. ISBN 978-0073378251.
- Becker, DG; Becker, SS (2003). "Treatment of nasal obstruction from nasal valve collapse with alar batten grafts". Journal of Long-Term Effects of Medical Implants. 13 (3): 259–69. doi:10.1615/JLongTermEffMedImplants.v13.i3.100. PMID 14516189.
- Pecorari, G; Riva, G; Bianchi, FA; Cavallo, G; Revello, F; Bironzo, M; Verzè, L; Garzaro, M; Ramieri, G (1 September 2017). "The effect of closed septorhinoplasty on nasal functions and on external and internal nasal valves: A prospective study". American Journal of Rhinology & Allergy. 31 (5): 323–327. doi:10.2500/ajra.2017.31.4459. PMID 28859710.
- Fischer, H; Gubisch, W (November 2006). "Nasal valves--importance and surgical procedures". Facial Plastic Surgery : FPS. 22 (4): 266–80. doi:10.1055/s-2006-954845. PMID 17131269.
- Wolfram-Gabel, R; Sick, H (February 2002). "Microvascularization of the mucocutaneous junction of the nose". Surgical and Radiologic Anatomy. 24 (1): 27–32. doi:10.1007/s00276-002-0009-6. PMID 12197007.
- Saladin, K (2011). Human anatomy (3rd ed.). McGraw-Hill. p. 480. ISBN 9780071222075.
- "Medical Definition of leptorrhine". www.merriam-webster.com.
- "Definition of Hyperleptorrhine". www.merriam-webster.com.
- Roe, J. O. (1 February 1989). "The Deformity Termed 'Pug Nose' and Its Correction by a Simple Operation". Archives of Otolaryngology–Head & Neck Surgery. 115 (2): 156–157. doi:10.1001/archotol.1989.01860260030010. PMID 2643972.
- Schreiber, BE; Twigg, S; Marais, J; Keat, AC (April 2014). "Saddle-nose deformities in the rheumatology clinic". Ear, Nose, & Throat Journal. 93 (4–5): E45–7. PMID 24817241.
- Sonek, JD; Cicero, S; Neiger, R; Nicolaides, KH (November 2006). "Nasal bone assessment in prenatal screening for trisomy 21". American Journal of Obstetrics and Gynecology. 195 (5): 1219–30. doi:10.1016/j.ajog.2005.11.042. PMID 16615922.
- Persico, N; et al. (March 2012). "Nasal bone assessment in fetuses with trisomy 21 at 16-24 weeks of gestation by three-dimensional ultrasound". Prenatal Diagnosis. 32 (3): 240–4. doi:10.1002/pd.2938. PMID 22430721.
- Chiu, TW; Shaw-Dunn, J; McGarry, GW (October 2008). "Woodruff's plexus". The Journal of Laryngology and Otology. 122 (10): 1074–7. doi:10.1017/S002221510800176X. PMID 18289456.
- Moore, Keith L.; Agur, A. M. R.; Dalley (Ii), Arthur F. (September 2017). Clinically Oriented Anatomy. pp. 865–867. ISBN 9781496347213.
- Sadler, T (2006). Langman's Medical Embryology. pp. 280–284. ISBN 9780781790697.
- Larsen, W (2001). Human Embryology. pp. 365–371. ISBN 0443065837.
- Hengerer AS, Oas RE (1987). Congenital Anomalies of the Nose: Their Embryology, Diagnosis, and Management (SIPAC). Alexandria VA: American Academy of Otolaryngology.[page needed]
- "Polyrrhinia (Concept Id: C4274730) - MedGen - NCBI". www.ncbi.nlm.nih.gov.
- Nasal Anatomy at eMedicine
- Van Cauwenberge, P; Sys, L; De Belder, T; Watelet, JB (February 2004). "Anatomy and physiology of the nose and the paranasal sinuses". Immunology and Allergy Clinics of North America. 24 (1): 1–17. doi:10.1016/S0889-8561(03)00107-3. PMID 15062424.
- Betlejewski, S; Betlejewski, A (2008). "[The influence of nasal flow aerodynamics on the nasal physiology]". Otolaryngologia Polska = the Polish Otolaryngology. 62 (3): 321–5. doi:10.1016/S0030-6657(08)70263-4. PMID 18652158.
- Jones, N (23 September 2001). "The nose and paranasal sinuses physiology and anatomy". Advanced Drug Delivery Reviews. 51 (1–3): 5–19. doi:10.1016/S0169-409X(01)00172-7. PMID 11516776.
- Geurkink, N (August 1983). "Nasal anatomy, physiology, and function". The Journal of Allergy and Clinical Immunology. 72 (2): 123–8. doi:10.1016/0091-6749(83)90518-3. PMID 6350406.
- Songu, M; Cingi, C (June 2009). "Sneeze reflex: facts and fiction". Therapeutic Advances in Respiratory Disease. 3 (3): 131–41. doi:10.1177/1753465809340571. PMID 19617285.
- García-Moreno, J. M. (January 2006). "Photic sneeze reflex or autosomal dominant compelling helio-ophthalmic outburst syndrome". Neurologia (Barcelona, Spain). 21 (1): 26–33. PMID 16525923.
- Bluestone, Charles (2002). Pediatric otolaryngology. Elsevier Health Sciences. ISBN 978-0-7216-9197-8.
- Tortora, G; Anagnostakos, N (1987). Principles of anatomy and physiology (5th. Harper international ed.). Harper & Row. p. 144. ISBN 978-0063507296.
- Moore, Keith; Dalley, Arthur; Agur, Anne (2018). Clinically oriented anatomy (Eighth ed.). Wolters Kluwer. pp. 864–869. ISBN 9781496347213.
- ""Snoring Causes". Mayo Clinic. Mayo Clinic. 26 April 2015. Retrieved 15 June 2016.
- "Nasal flaring: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 15 June 2019.
- "Foreign Body, Nose". Archived from the original on 2008-12-20. Retrieved 2008-12-16.
- "Frostbite - Symptoms and causes". Mayo Clinic.
- Cukurova, I; Yaz, A; Gumussoy, M; Yigitbasi, OG; Karaman, Y (26 March 2012). "A patient presenting with concha bullosa in another concha bullosa: a case report". Journal of Medical Case Reports. 6: 87. doi:10.1186/1752-1947-6-87. PMC 3338398. PMID 22448660.
- Erkan, AN; Canbolat, T; Ozer, C; Yilmaz, I; Ozluoglu, LN (8 May 2006). "Polyp in concha bullosa: a case report and review of the literature". Head & Face Medicine. 2: 11. doi:10.1186/1746-160X-2-11. PMC 1471777. PMID 16681852.
- Rodrigo Tapia, JP; Alvarez Alvarez, I; Casas Rubio, C; Blanco Mercadé, A; Díaz Villarig, JL (August 1999). "[A giant bilateral concha bullosa causing nasal obstruction]". Acta Otorrinolaringologica Espanola. 50 (6): 490–2. PMID 10502705.
- Menick, F (November 2014). "Primary intranasal lining injury cause, deformities, and treatment plan". Plast Reconstr Surg. 134 (5): 1045–56. doi:10.1097/PRS.0000000000000694. PMID 25347637.
- Tellier, R; Li, Y; Cowling, BJ; Tang, JW (31 January 2019). "Recognition of aerosol transmission of infectious agents: a commentary". BMC Infectious Diseases. 19 (1): 101. doi:10.1186/s12879-019-3707-y. PMC 6357359. PMID 30704406.
- Silva, EN (February 2019). "The Relation Between the Lower Lateral Cartilages and the Function of the External Nasal Valve". Aesthetic Plastic Surgery. 43 (1): 175–183. doi:10.1007/s00266-018-1195-x. PMID 30019240.
- Kühnel, T. S.; Reichert, T. E. (2015). "Trauma of the midface". GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery. 14: Doc06. doi:10.3205/cto000121. PMC 4702055. PMID 26770280.
- Kumar, A; Yadav, N; Singh, N; Chauhan, N (December 2016). "Minimally invasive (endoscopic-computer assisted) surgery:Technique and review". Annals of Maxillofacial Surgery. 6 (2): 159–164. doi:10.4103/2231-0746.200348. PMC 5343621. PMID 28299251.
- Komotar, RJ; Starke, RM; Raper, DM; Anand, VK; Schwartz, TH (February 2012). "Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of craniopharyngiomas". World Neurosurgery. 77 (2): 329–41. doi:10.1016/j.wneu.2011.07.011. PMID 22501020.
- Ye, T; Zhou, B (February 2015). "Update on surgical management of adult inferior turbinate hypertrophy". Current opinion in otolaryngology & head and neck surgery. 23 (1): 29–33. doi:10.1097/MOO.0000000000000130. PMID 25565284.
- "Miss Universe Malaysia pageant contestants 'look too western'". 2018-11-28. Archived from the original on 2016-09-22.
- Strochlic, Nina (6 January 2014). "DIY Plastic Surgery: Can You Change Your Face Without Going Under the Knife?". The Daily Beast.
- "Connecting People Through News". PressReader. Archived from the original on 2017-12-06.
- "Nose Shaper". Shybuy. Archived from the original on 2017-06-05.
- Marc S. Abramson (2011). Ethnic Identity in Tang China. University of Pennsylvania Press. p. 88. ISBN 978-0-8122-0101-7. Archived from the original on 2018-05-02.
- Johann Jakob Meyer (1989). Sexual Life in Ancient India: A Study in the Comparative History of Indian Culture. Motilal Banarsidass. p. 433. ISBN 978-81-208-0638-2. Archived from the original on 2018-05-02.
- Derby, Mark (September 2013). "Ngā mahi tika". Te Ara – the Encyclopedia of New Zealand. Archived from the original on 8 September 2017. Retrieved 8 September 2017.
- "Greetings! Hongi Style! – polynesia.com | blog". polynesia.com | blog. 2016-03-24. Archived from the original on 2017-09-18. Retrieved 2017-09-18.
- Sansom, George Bailey (1961). A History of Japan, 1334–1615. Stanford studies in the civilizations of eastern Asia. Stanford University Press. p. 360. ISBN 978-0-8047-0525-7.
Visitors to Kyoto used to be shown the Minizuka or Ear Tomb, which contained, it was said, the noses of those 38,000, sliced off, suitably pickled, and sent to Kyoto as evidence of victory.
- Pray, W. Steven (2005). Nonprescription Product Therapeutics. p. 221: Lippincott Williams & Wilkins. ISBN 978-0781734981.
- Mitali Ruths (June 14, 2011). "White Line on Nose in Children". LiveStrong.com. Archived from the original on 2012-06-22. Retrieved 2012-11-25.
- "nasophilia". The Free Dictionary.
- Finlayson, C (2004). Neanderthals and modern humans: an ecological and evolutionary perspective. Cambridge University Press. pp. 84. ISBN 978-0-521-82087-5.
- Rae, T.C. (2011). "The Neanderthal face is not cold adapted". Journal of Human Evolution. 60 (2): 234–239. doi:10.1016/j.jhevol.2010.10.003. PMID 21183202.
- Hernández, M.; Fox, C. L.; Garcia-Moro, C. (1997). "Fueguian cranial morphology: The adaptation to a cold, harsh environment". American Journal of Physical Anthropology. 103 (1): 103–117. doi:10.1002/(SICI)1096-8644(199705)103:1<103::AID-AJPA7>3.0.CO;2-X. PMID 9185954.
- Gould, S.J. (1996). The mismeasure of man. Norton and Company: NY.[page needed]
- Jones, Doug (1995). "Sexual Selection, Physical Attractiveness, and Facial Neoteny: Cross-cultural Evidence and Implications". Current Anthropology. 36 (5): 723–48. doi:10.1086/204427. JSTOR 2744016.
- Oshima J, Martin GM, Hisama FM (2002-12-02) [Updated 2016-09-29]. Adam MP, Ardinger HH, Pagon RA, et al. (eds.). "Werner Syndrome". GeneReviews®. Seattle, WA: University of Washington. Archived from the original on 2017-01-18. Retrieved 2017-08-31 – via NCBI.
- Opitz, John M.; Gilbert-Barness, Enid F. (2005). "Reflections on the pathogenesis of Down syndrome". American Journal of Medical Genetics. 37: 38–51. doi:10.1002/ajmg.1320370707. PMID 2149972.
- From the Nose to the Eustachian Tube: Information, videos, tips for diving
- Your Nose: The Guardian Of Your Lungs
- Media related to Noses at Wikimedia Commons
- Quotations related to Noses at Wikiquote