Haplogroup JT (mtDNA)

Haplogroup JT is a human mitochondrial DNA (mtDNA) haplogroup.

Haplogroup JT
Possible time of origin50,300 YBP
Possible place of originSouthwest Asia
DescendantsJ, T
Defining mutations11251, 15452A, 16126[1]


Haplogroup JT is descended from the macro-haplogroup R. It is the ancestral clade to the mitochondrial haplogroups J and T.

JT (predominantly J) was found among the ancient Etruscans.[2] The haplogroup has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site.[3] One ancient individual carried a haplotype, which correlates with either the JT clade or the haplogroup H subclade H14b1 (1/9; 11%).[4]




This phylogenetic tree of haplogroup JT subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[1] and subsequent published research.

  • R2'JT


Maternally inherited ancient mtDNA variants have clear impact on the presentation of disease in a modern society. Superhaplogroup JT is an example of reduced risk of Parkinson’s disease[5] And mitochondrial and mtDNa alterations continue to be promising disease biomarkers.[6][7]

See alsoEdit

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U


  1. ^ a b van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457.
  2. ^ http://www.jogg.info/22/Coffman.htm
  3. ^ Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González (2014). "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents". BMC Evolutionary Biology. 14: 109. doi:10.1186/1471-2148-14-109. PMC 4062890. PMID 24885141.
  4. ^ Kefi, Rym; et al. (2016). "On the origin of Iberomaurusians: new data based on ancient mitochondrial DNA and phylogenetic analysis of Afalou and Taforalt populations". Mitochondrial DNA Part A. 29 (1): 147–157. doi:10.1080/24701394.2016.1258406. PMID 28034339. S2CID 4490910.
  5. ^ Marom S, Friger M, Mishmar D. MtDNA meta-analysis reveals both phenotype specificity and allele heterogeneity: a model for differential association. Sci Rep. 2017 Feb 23;7:43449. doi: 10.1038/srep43449. PMID: 28230165; PMCID: PMC5322532.
  6. ^ Rebeca Martín-Jiménez, Olivier Lurette, and Etienne Hebert-Chatelain.DNA and Cell Biology.Aug 2020.1421-1430.http://doi.org/10.1089/dna.2020.5398
  7. ^ Mitochondrion. 2019 May; 46: 307–312.doi: 10.1016/j.mito.2018.07.008

External linksEdit