He was the scion of a family of great sages, and the brother of R. Hoshaiah Rabbah. Hoshaiah is once referred to as "Rabbi Hoshaiah bar Rabbi Hama", which suggests that Hanina is the same as Hanina bar Hama, though other opinions suggest they were different individuals.
Hanina was a bachelor all his life, and together with his brother Hoshaiah sold shoes for prostitutes, and yet they did not raise their eyes to see them. Rava used to say that on these two brothers it is said that if a bachelor who lives in a city and does not sin, God declares him every day.
Several stories indicate that he had extensive medical knowledge.
R. Yochanan bar Nafcha wanted to ordain him a Rabbi but failed, until R. Hanina explained to him that he is a descendant of the house of Eli the priest, on whom upon a curse was uttered: " and there shall not be an elder in thy house for ever". A curse that is aimed in its biblical sense, "an elder" – a Rabbi – a descendant of Eli.
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