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3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.[5][6][7][8]

HSD17B7
Identifiers
AliasesHSD17B7, PRAP, SDR37C1, hydroxysteroid (17-beta) dehydrogenase 7, hydroxysteroid 17-beta dehydrogenase 7
External IDsMGI: 1330808 HomoloGene: 40728 GeneCards: HSD17B7
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HSD17B7
Genomic location for HSD17B7
Band1q23.3Start162,790,702 bp[1]
End162,812,817 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001304512
NM_001304513
NM_016371

NM_010476

RefSeq (protein)

NP_001291441
NP_001291442
NP_057455

NP_034606

Location (UCSC)Chr 1: 162.79 – 162.81 MbChr 1: 169.95 – 169.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM][8]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132196 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026675 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Krazeisen A, Breitling R, Imai K, Fritz S, Moller G, Adamski J (Dec 1999). "Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1)". FEBS Lett. 460 (2): 373–9. doi:10.1016/S0014-5793(99)01366-6. PMID 10544267.
  6. ^ Peltoketo H, Nokelainen P, Piao YS, Vihko R, Vihko P (Aug 1999). "Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7". J Steroid Biochem Mol Biol. 69 (1–6): 431–9. doi:10.1016/S0960-0760(99)00064-3. PMID 10419022.
  7. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  8. ^ a b "Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7".

Further readingEdit