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Major histocompatibility complex, class II, DP alpha 1

  (Redirected from HLA-DPA1)

Major histocompatibility complex, class II, DP alpha 1, also known as HLA-DPA1, is a human gene.[1]

major histocompatibility complex, class II, DP alpha 1
Identifiers
SymbolHLA-DPA1
Alt. symbolsHLA-DP1A
Entrez3113
HUGO4938
OMIM142880
RefSeqNM_033554
UniProtP20036
Other data
LocusChr. 6 p21.3

Contents

FunctionEdit

The protein encoded by this gene belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).[1]

Gene structure and polymorphismsEdit

The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.[1]

See alsoEdit

ReferencesEdit

  1. ^ a b c "Entrez Gene: HLA-DPA1 major histocompatibility complex, class II, DP alpha 1".


This article incorporates text from the United States National Library of Medicine, which is in the public domain.