HIST1H4E

Histone H4 is a protein that in humans is encoded by the HIST1H4E gene.

H4C5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifiers
Aliases	H4C5, H4/j, H4FJ, histone cluster 1, H4e, histone cluster 1 H4 family member e, H4 clustered histone 5, HIST1H4E, H4C4, H4C9, H4C12, H4-16, H4C2, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6
External IDs	OMIM: 602830 HomoloGene: 134463 GeneCards: H4C5
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 26,204,610 bp End 26,205,021 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells internal globus pallidus Achilles tendon corpus callosum right uterine tube thymus sural nerve amniotic fluid prostate blood n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein domain specific binding protein binding protein heterodimerization activity DNA binding histone binding RNA binding Cellular component membrane chromosome nucleoplasm extracellular region nuclear chromosome nucleosome extracellular exosome nucleus extracellular matrix protein-containing complex Biological process telomere organization epigenetic maintenance of chromatin in transcription-competent conformation protein heterotetramerization negative regulation of megakaryocyte differentiation CENP-A containing chromatin assembly DNA replication-dependent chromatin assembly rDNA heterochromatin assembly negative regulation of gene expression, epigenetic DNA-templated transcription, initiation double-strand break repair via nonhomologous end joining beta-catenin-TCF complex assembly telomere capping nucleosome assembly regulation of gene silencing by miRNA regulation of megakaryocyte differentiation regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8367 n/a Ensembl ENSG00000276966 n/a UniProt P62805 n/a RefSeq (mRNA) NM_003545 n/a RefSeq (protein) NP_003537 NP_003486 NP_003535 NP_003539 NP_003531 NP_003536 n/a Location (UCSC) Chr 6: 26.2 – 26.21 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Further reading

• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.