Guillén or Guillen is a Spanish or French surname. Notable people with the surname include:
- Alanis Guillen (born 1998), Brazilian actress.
- Ambrosio Guillen (1929–1953), United States Marine who was posthumously awarded the Medal of Honor
- Carlos Guillén, retired Venezuelan baseball player
- Charlie Guillen, American writer and filmmaker
- Fernando Guillén (disambiguation), multiple people
- Harvey Guillén (born 1990), actor
- Jorge Guillén, Spanish poet
- José Guillén (born 1976), Dominican baseball player
- Juan Manuel Guillén, El Salvadoran artist, digital producer for LCBO
- Laurice Guillén (born 1947), Filipina actress
- Montserrat Guillén (born 1964), Spanish statistician and economist
- Nancy Guillén (born 1976), retired Salvadoran hammer thrower
- Néstor Guillén Olmos (1890–1966), President of Bolivia for 27 days
- Nicolás Guillén, Afro-Cuban poet
- Ozzie Guillén (born 1964), Venezuelan baseball coach and former player
- Osiel Cárdenas Guillén (born 1967), Mexican drug lord
- Rafael Guillen ("Subcomandante Marcos"), spokesman for the Zapatista Army of National Liberation
- Ricardo Guillén (born 1967), Spanish basketball player
- Sammy Guillen (1924–2013), West Indian and New Zealand cricket player
- Tonatiuh Guillén López, Mexican academic and government official, Mexico's immigration chief since December 2018
- Vanessa Guillen, American soldier
- Walter Guillén Soto, Catholic bishop in Honduras
This page lists people with the surname Guillén.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.