Gamma-glutamyltransferase 6

  (Redirected from GGT6 (gene))

Gamma-glutamyltransferase 6 is a protein that in humans is encoded by the GGT6 gene. [5]

GGT6
Identifiers
AliasesGGT6, gamma-glutamyltransferase 6
External IDsOMIM: 612341 MGI: 1918772 HomoloGene: 51918 GeneCards: GGT6
EC number3.4.19.13
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for GGT6
Genomic location for GGT6
Band17p13.2Start4,556,927 bp[1]
End4,560,818 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153338
NM_001122890
NM_001288702
NM_001288703
NM_001288704

NM_027819

RefSeq (protein)

NP_001116362
NP_001275631
NP_001275632
NP_001275633
NP_699169

NP_082095

Location (UCSC)Chr 17: 4.56 – 4.56 MbChr 11: 72.44 – 72.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FunctionEdit

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167741 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040471 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Gamma-glutamyltransferase 6". Retrieved 2016-03-11.

Further readingEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.