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Glucose-6-phosphatase, catalytic subunit (glucose 6-phosphatase alpha) is an enzyme that in humans is encoded by the G6PC gene.[5][6]

G6PC
Identifiers
AliasesG6PC, G6PC1, G6PT, GSD1, GSD1a, G6Pase, glucose-6-phosphatase catalytic subunit
External IDsOMIM: 613742 MGI: 95607 HomoloGene: 20079 GeneCards: G6PC
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for G6PC
Genomic location for G6PC
Band17q21.31Start42,900,797 bp[1]
End42,914,438 bp[1]
RNA expression pattern
PBB GE G6PC 206952 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270397
NM_000151

NM_008061

RefSeq (protein)

NP_000142
NP_001257326

NP_032087

Location (UCSC)Chr 17: 42.9 – 42.91 MbChr 11: 101.37 – 101.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease).[6]

Interactive pathway mapEdit

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]
Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

See alsoEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131482 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078650 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Brody LC, Abel KJ, Castilla LH, Couch FJ, McKinley DR, Yin G, Ho PP, Merajver S, Chandrasekharappa SC, Xu J, et al. (Jul 1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17". Genomics. 25 (1): 238–47. doi:10.1016/0888-7543(95)80131-5. PMID 7774924.
  6. ^ a b "Entrez Gene: G6PC glucose-6-phosphatase, catalytic subunit".

Further readingEdit