File:The Tailchaser mutation does not affect formation of interstereocilial links.png

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Summary

Description
English: High resolution SEM images showing stereocilia bundles on outer (A–C, G–N) and inner (D–F) hair cells of wild type (A, D, G, H, K and L), Tlc/+ (B, E, I, M) and Tlc/Tlc (C, F, J and N) mice at P21 (G–J) and P7 (K–N). Note misshaped but staircase-like stereocilia bundles on hair cells of Tlc/+ animals (B and E) and disorganized bundles formed from fewer stereocilia of Tlc/Tlc mice (C and F). The horizontal connectors, tip links (G–J, tip links indicated by arrowheads, horizontal connectors indicated by arrows, inset on J shows high magnification image of tip link found between Tlc/Tlc stereocilia), lateral and ankle links (K–N, lateral links indicated by arrows, ankle links indicated by arrowheads) are present between Tlc/+ and Tlc/Tlc stereocilia and are indistinguishable from those of wild type mice. Scale bars: A–F-2 µm; G, H, K, L, N–200 nm; I, J and M–500 nm.
Date
Source A Myo6 Mutation Destroys Coordination between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian Inner Ear Hair Cells ([1])
Author Ronna Hertzano, Ella Shalit, Agnieszka K. Rzadzinska, Amiel A. Dror, Lin Song, Uri Ron, Joshua T. Tan, Alina Starovolsky Shitrit, Helmut Fuchs, Tama Hasson, Nir Ben-Tal, H. Lee Sweeney, Martin Hrabe de Angelis, Karen P. Steel, Karen B. Avraham


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3 October 2008

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current00:11, 13 February 2009Thumbnail for version as of 00:11, 13 February 20092,756 × 2,792 (6.41 MB)Mike.lifeguard{{Information |Description={{en|1=High resolution SEM images showing stereocilia bundles on outer (A–C, G–N) and inner (D–F) hair cells of wild type (A, D, G, H, K and L), Tlc/+ (B, E, I, M) and Tlc/Tlc (C, F, J and N) mice at P21 (G–J) and P7 (K�
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