Failure to thrive
Failure to thrive (FTT), more recently known as faltering weight or weight faltering, is a term used in pediatric medicine, as well as veterinary medicine (where it is also referred to as ill-thrift), to indicate insufficient weight gain or inappropriate weight loss. When not more precisely defined, the term refers to pediatric patients. In children, it is usually defined in terms of weight, and can be evaluated either by a low weight for the child's age, or by a low rate of increase in the weight.
|Failure to thrive|
|Classification and external resources|
The term ‘failure to thrive’ has been used vaguely and in different contexts to refer to different issues in pediatric growth. It is most commonly used to describe a failure to gain weight, but some providers have also used it to describe a failure to grow, or a failure to grow and to gain weight. As used by pediatricians, it covers poor physical growth of any cause. The term has been used in different ways, and different objective standards have been defined. FTT is suggested by a fall in one or more weight centile spaces on a World Health Organization (WHO) growth chart depending on birth weight or when weight is below the 2nd percentile of weight for age irrespective of birth weight. In children whose birth weight was between the 9th and 91st percentile FTT is indicated by a drop across 2 or more centile spaces. Weight loss after birth is normal and most babies return to their birth weight by 3 weeks of age. Clinical assessment for FTT is recommended for babies who lose more than 10% of their birth weight or do not return to their birth weight after 3 weeks.
FTT was first introduced in the early 20th century to describe poor growth in orphan children but became associated with negative implications (such as maternal deprivation) that often incorrectly explained the underlying issues. Throughout the 20th century, FTT was expanded to include many different issues related to poor growth, which made it broadly applicable but non-specific. The current conceptualization of FTT acknowledges the complexity of faltering growth in children and has shed many of the negative stereotypes that plagued previous definitions.
Failure to thrive occurs in children whose nutritional intake is insufficient for supporting normal growth and weight gain. Failure to thrive typically presents before 2 years of age, when growth rates are highest. Parents may express concern about picky eating habits, poor weight gain, or smaller size compared relative to peers of similar age. Physicians often identify failure to thrive during routine office visits, when a child's growth parameters are not tracking appropriately on growth curves.
Traditionally, causes of FTT have been divided into endogenous and exogenous causes. These causes can be largely grouped into three categories: inadequate caloric intake, malabsorption/caloric retention defect, and increased metabolic demands. Initial investigation should consider prenatal history, postnatal history, past medical history, feeding history to assess overall caloric intake, developmental history, family history, and psychosocial history.
- Endogenous (or "organic")
- Causes are due to physical or mental issues with the child itself. It can include various inborn errors of metabolism. Problems with the gastrointestinal system such as excessive gas and acid reflux are painful conditions which may make the child unwilling to take in sufficient nutrition. Cystic fibrosis, diarrhea, liver disease, anemia or iron deficiency, and coeliac disease make it more difficult for the body to absorb nutrition. Other causes include physical deformities such as cleft palate and tongue tie. Milk allergies can cause endogenous FTT. Also the metabolism may be raised by parasites, asthma, urinary tract infections, and other fever-inducing infections, hyperthyroidism or congenital heart disease, so that it becomes difficult to get in sufficient calories to meet the higher caloric demands.
- Exogenous (or "nonorganic")
- Caused by caregiver's actions. Examples include physical inability to produce enough breastmilk, using only babies' cues to regulate breastfeeding so as to not offer a sufficient number of feeds (sleepy baby syndrome). A recent study on toddlers with exogenous FTT has found preliminary evidence suggesting that difficulty experienced during feeding times with this condition may in fact be impacted by preexisting sensory processing problems. Such difficulties with sensory processing are more commonly observed in toddlers who have a history of growth deficiency and feeding problems; however, further research is required in order to determine a causal relationship between sensory processing problems and nonorganic FTT. In developing countries, conflict settings and protracted emergencies, exogenous faltering may be caused by chronic food insecurity, lack of nutritional awareness, and other factors beyond the caregiver's control. As many as 90% of failure to thrive cases are non-organic.
- However, to think of the terms as dichotomous can be misleading, since both endogenous and exogenous factors may co-exist. For instance a child who is not getting sufficient nutrition may act content so that caregivers do not offer feedings of sufficient frequency or volume, and a child with severe acid reflux who appears to be in pain while eating may make a caregiver hesitant to offer sufficient feedings.
Differential Diagnosis by EtiologyEdit
Inadequate Caloric IntakeEdit
- Poverty/Inadequate food supply - number one risk factor for failure to thrive globally
- Improper mixing of formula
- Postpartum depression/maternal depression - studies have shown that mothers with postpartum depression are at increased risk for experiencing breastfeeding difficulties
- Child neglect - prevalence of neglect in non-organic failure to thrive is estimated to be as high as 5-10%
- Cleft lip and cleft palate - impaired oral motor coordination/poor suck
- Cerebral palsy/Hypotonia
- Gastroesophageal reflux disease - symptoms of irritability, fussiness, and spitting up that occur shortly after feeding. Typically resolves by 1–2 years of age.
- Pyloric stenosis - Most commonly presents at 1–2 months of age with forceful, projectile vomiting immediately after feeds. More common in first-born males,
Malabsorption/Caloric Retention DefectEdit
- Lactose intolerance/Cow's milk protein allergy - affects 2-3% of infants during the first year of life
- Coeliac disease
- Short bowel syndrome - necrotizing enterocolitis is the most common cause.
- Cystic fibrosis
- Biliary atresia
Increased Metabolic DemandEdit
- Chronic infections - tuberculosis, HIV
- TORCH infections
- Inflammatory bowel disease
- Diabetes mellitus
- Congenital heart defects
- Chronic lung disease - bronchopulmonary dysplasia, bronchiectasis
- Inborn errors of metabolism - galactosemia, glycogen storage diseases
FTT may be evaluated through a multifaceted process, beginning with a patient history that notably includes diet history, which is a key element for identifying potential causes of FTT. Next, a complete physical examination may be done, with special attention being paid to identifying possible organic sources of FTT. This could include looking for dysmorphic features, abnormal breathing sounds, and signs of specific vitamin and mineral deficiencies. The physical exam may also reveal signs of possible child neglect or abuse. Based on the information gained from the history and physical examination, a workup can then be conducted, in which possible sources of FTT can be further probed, through blood work, X-rays, or other tests. Laboratory workup should be directed by concerning history and physical examination findings, as it is estimated that the usefulness of laboratory investigations for children with failure to thrive is 1.4%.
Infants and children who have had unpleasant eating experiences (e.g. acid reflux or food intolerance) may be reluctant to eat their meals. Additionally, force feeding an infant or child can discourage proper self-feeding practices and in-turn cause undue stress on both the child and their parents. Psychosocial interventions can be targeted at encouraging the child to feed themselves during meals. Also, making mealtimes a positive, enjoyable experience through the use of positive reinforcement may improve eating habits in children who present with FTT. If behavioural issues persist and are affecting nutritional habits in children with FTT it is recommended that the child see a psychologist. If an underlying condition, such as inflammatory bowel disease, is identified as the cause of the child's failure to thrive then treatment is directed towards the underlying condition.
Children with failure to thrive are at an increased risk for long-term growth, cognitive, and behavioral complications. Studies have shown that children with failure to thrive during infancy were shorter and lower weight at school-age than their peers. Failure to thrive may also result in children not achieving their growth potential, as estimated by mid-parental height. Longitudinal studies have also demonstrated lower IQs (3-5 points) and poorer arithmetic performance in children with a history failure to thrive, compared to peers receiving adequate nutrition as infants and toddlers. Early intervention and restoration of adequate nutrition has been shown to reduce the likelihood of long-term sequelae, however, studies have shown that failure to thrive may cause persistent behavioral problems, despite appropriate treatment.
Failure to thrive is a common presenting problem in the pediatric population. Failure to thrive is very prevalent in the United States, representing 5-10% of children seen as outpatients by primary care physicians. Failure to thrive is more prevalent in children of lower socioeconomic status. Failure to thrive accounts for 3-5% of all hospital admissions for children under two years of age. Retrospective studies suggest that males are slightly more likely than females to be admitted to the hospital for failure to thrive (53.2% vs. 46.7%).
- Shields B, Wacogne I, Wright CM (September 2012). "Weight faltering and failure to thrive in infancy and early childhood". BMJ. 345 (sep25 1): e5931. doi:10.1136/bmj.e5931. PMID 23014901.
- "Failure to Thrive: Miscellaneous Disorders in Infants and Children: Merck Manual Professional". Retrieved 2010-03-23.
- Al Nofal A, Schwenk WF (December 2013). "Growth failure in children: a symptom or a disease?". Nutrition in Clinical Practice. 28 (6): 651–8. doi:10.1177/0884533613506015. PMID 24170580.
- Scholler I, Nittur S (2012-10-01). "Understanding failure to thrive". Paediatrics and Child Health. 22 (10): 438–442. doi:10.1016/j.paed.2012.02.007.
- Hughes I (February 2007). "Confusing terminology attempts to define the undefinable". Archives of Disease in Childhood. 92 (2): 97–8. doi:10.1136/adc.2006.108423. PMC . PMID 17264278.
- Raynor P, Rudolf MC (May 2000). "Anthropometric indices of failure to thrive". Archives of Disease in Childhood. 82 (5): 364–5. doi:10.1136/adc.82.5.364. PMC . PMID 10799424.
- Olsen EM, Petersen J, Skovgaard AM, Weile B, Jørgensen T, Wright CM (February 2007). "Failure to thrive: the prevalence and concurrence of anthropometric criteria in a general infant population". Archives of Disease in Childhood. 92 (2): 109–14. doi:10.1136/adc.2005.080333. PMC . PMID 16531456.
- National Guideline Alliance (UK) (2017). Faltering Growth – recognition and management. National Institute for Health and Care Excellence: Clinical Guidelines. London: National Institute for Health and Care Excellence (UK). ISBN 978-1-4731-2693-0. PMID 28991420.
- "Weight-for-age Child growth standards". World Health Organization. Retrieved 2017-11-15.
- Estrem HH, Pados BF, Park J, Knafl KA, Thoyre SM (January 2017). "Feeding problems in infancy and early childhood: evolutionary concept analysis". Journal of Advanced Nursing. 73 (1): 56–70. doi:10.1111/jan.13140. PMID 27601073.
- Zitelli BJ, McIntire SC, Nowalk AJ (2012). Zitelli and Davis' atlas of pediatric physical diagnosis (Sixth ed.). Philadelphia, PA: Saunders/Elsevier. ISBN 978-0-323-07932-7. OCLC 793494374.
- Kliegman R, Lye PS, Bordini BJ, Toth H, Basel D (2018). Nelson pediatric symptom-based diagnosis. Philadelphia, PA. ISBN 978-0-323-39956-2. OCLC 986243536.
- Homan GJ (August 2016). "Failure to Thrive: A Practical Guide". American Family Physician. 94 (4): 295–9. PMID 27548594.
- Habbick BF, Gerrard JW (October 1984). "Failure to thrive in the contented breast-fed baby". Canadian Medical Association Journal. 131 (7): 765–8. PMC . PMID 6541091.
- Yi SH, Joung YS, Choe YH, Kim EH, Kwon JY (June 2015). "Sensory Processing Difficulties in Toddlers With Nonorganic Failure-to-Thrive and Feeding Problems". Journal of Pediatric Gastroenterology and Nutrition. 60 (6): 819–24. doi:10.1097/mpg.0000000000000707. PMID 25564810.
- Prendergast AJ, Humphrey JH (November 2014). "The stunting syndrome in developing countries". Paediatrics and International Child Health. 34 (4): 250–65. doi:10.1179/2046905514Y.0000000158. PMC . PMID 25310000.
- Jaffe AC (March 2011). "Failure to thrive: current clinical concepts". Pediatrics in Review. 32 (3): 100–7; quiz 108. doi:10.1542/pir.32-3-100. PMID 21364013.
- Patel V, DeSouza N, Rodrigues M (January 2003). "Postnatal depression and infant growth and development in low income countries: a cohort study from Goa, India". Archives of Disease in Childhood. 88 (1): 34–7. doi:10.1136/adc.88.1.34. PMC . PMID 12495957.
- "Understanding failure to thrive". Paediatrics and Child Health. 22 (10): 438–442. 2012-10-01. doi:10.1016/j.paed.2012.02.007. ISSN 1751-7222.
- "Frequency of cow's milk allergy in childhood". Annals of Allergy, Asthma & Immunology. 89 (6): 33–37. 2002-12-01. doi:10.1016/S1081-1206(10)62120-5. ISSN 1081-1206.
- Wales PW, Christison-Lagay ER (February 2010). "Short bowel syndrome: epidemiology and etiology". Seminars in Pediatric Surgery. 19 (1): 3–9. doi:10.1053/j.sempedsurg.2009.11.001. PMID 20123268.
- Marchand V (October 2012). "The toddler who is falling off the growth chart". Paediatrics & Child Health. 17 (8): 447–54. PMC . PMID 24082808.
- Larson-Nath C, Biank VF (February 2016). "Clinical Review of Failure to Thrive in Pediatric Patients". Pediatric Annals. 45 (2): e46–9. doi:10.3928/00904481-20160114-01. PMID 26878182.
- Boddy J, Skuse D, Andrews B (November 2000). "The developmental sequelae of nonorganic failure to thrive". Journal of Child Psychology and Psychiatry, and Allied Disciplines. 41 (8): 1003–14. PMID 11099117.
- Black MM, Dubowitz H, Krishnakumar A, Starr RH (July 2007). "Early intervention and recovery among children with failure to thrive: follow-up at age 8". Pediatrics. 120 (1): 59–69. doi:10.1542/peds.2006-1657. PMID 17606562.
- Goh LH, How CH, Ng KH (June 2016). "Failure to thrive in babies and toddlers". Singapore Medical Journal. 57 (6): 287–91. doi:10.11622/smedj.2016102. PMID 27353148.
- Thompson RT, Bennett WE, Finnell SM, Downs SM, Carroll AE (March 2013). "Increased length of stay and costs associated with weekend admissions for failure to thrive". Pediatrics. 131 (3): e805–10. doi:10.1542/peds.2012-2015. PMID 23439903.