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Axial T2-weighted MRI of the brain at the level of the midbrain showing the characteristic ‘face of the giant panda’ sign, with normal red nuclei and substantia nigra (pars reticulata) against a background of hyperintensity in the tegmentum, as well as hypointensity of the superior colliculi.

The "Face of the Giant Panda" sign, "Panda Sign of the Midbrain," or "Double-Panda Sign" refers to a characteristic "panda's face" appearance in MRI images of patients suffering from Wilson's Disease. Along with Kayser–Fleischer rings, the sign is helpful in diagnosis.[1]


  1. ^ Kuruvilla, A.; Joseph, S. (2000). "'Face of the giant panda' sign in Wilson's disease: Revisited". Neurology India. 48 (4): 395–6. PMID 11146611.

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