Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene.[5][6] Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may influence tumour progression.[7]

FLOT2
Protein FLOT2 PDB 1win.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFLOT2, ECS-1, ECS1, ESA, ESA1, M17S1, flotillin 2
External IDsOMIM: 131560 MGI: 103309 HomoloGene: 3293 GeneCards: FLOT2
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for FLOT2
Genomic location for FLOT2
Band17q11.2Start28,879,335 bp[1]
End28,897,733 bp[1]
RNA expression pattern
PBB GE FLOT2 211299 s at fs.png

PBB GE FLOT2 201350 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004475
NM_001330170

RefSeq (protein)

NP_001317099
NP_004466

Location (UCSC)Chr 17: 28.88 – 28.9 MbChr 11: 78.04 – 78.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132589 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061981 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schroeder WT, Siciliano MJ, Stewart-Galetka SL, Duvic M (Feb 1992). "The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12". Genomics. 11 (2): 481–2. doi:10.1016/0888-7543(91)90166-C. PMID 1769667.
  6. ^ a b "Entrez Gene: FLOT2 flotillin 2".
  7. ^ Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M (Oct 2004). "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". Cancer Res. 64 (20): 7361–9. doi:10.1158/0008-5472.CAN-04-0823. PMID 15492257.

Further readingEdit