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Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.[5][6] Gamma-enolase is a phosphopyruvate hydratase.

ENO2
Protein ENO2 PDB 1te6.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesENO2, HEL-S-279, NSE, Enolase 2
External IDsOMIM: 131360 MGI: 95394 HomoloGene: 74414 GeneCards: ENO2
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ENO2
Genomic location for ENO2
Band12p13.31Start6,913,745 bp[1]
End6,923,698 bp[1]
RNA expression pattern
PBB GE ENO2 201313 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001975

NM_013509
NM_001302642
NM_001355220

RefSeq (protein)

NP_001966
NP_001966.1

NP_001289571
NP_038537
NP_001342149

Location (UCSC)Chr 12: 6.91 – 6.92 MbChr 6: 124.76 – 124.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.[5]

Contents

Interactive pathway mapEdit

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

UtilityEdit

 
Neuron-specific enolase (NSE) immunostaining of a cerebellar hemangioblastoma.

Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small-cell carcinomas, which are neuroendocrine in origin. NSE is therefore a useful tumor marker for distinguishing small-cell carcinomas from other tumors.[7]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111674 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004267 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "ENO2 enolase 2 (gamma, neuronal)". NCBI Entrez Gene database.
  6. ^ Online Mendelian Inheritance in Man (OMIM) Enolase 2 -131360
  7. ^ Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, Vessella RL, Nelson PS (April 2003). "Molecular characterization of prostatic small-cell neuroendocrine carcinoma". Prostate. 55 (1): 55–64. doi:10.1002/pros.10217. PMID 12640661.

Further readingEdit

External linksEdit

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Gamma-enolase