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Endothelial activation

Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels.[1] It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the early states of atherosclerosis and sepsis, among others.[2] It is also implicated in the formation of deep vein thrombosis.[3] As a result of activation, enthothelium releases Weibel–Palade bodies.[4]

See alsoEdit


  1. ^ Li X, Fang P, et al. (April 2016). "Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation". Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 1090–100. doi:10.1161/ATVBAHA.115.306964. PMC 4882253 . PMID 27127201. 
  2. ^ Alom-Ruiz SP, Anilkumar N, Shah AM (2008). "Reactive oxygen species and endothelial activation". Antioxid Redox Signal. 10 (6): 1089–100. doi:10.1089/ars.2007.2007. PMID 18315494. 
  3. ^ Bovill EG, van der Vliet A (2011). "Venous valvular stasis-associated hypoxia and thrombosis: what is the link?". Annu Rev Physiol. 73: 527–45. doi:10.1146/annurev-physiol-012110-142305. PMID 21034220. 
  4. ^ López JA, Chen J (2009). "Pathophysiology of venous thrombosis". Thromb Res. 123 (Suppl 4): S30–4. doi:10.1016/S0049-3848(09)70140-9. PMID 19303501. 

Further readingEdit