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Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase. Since tetrahydrofolate is needed to make both purines and pyrimidines, which are building blocks of DNA and RNA, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis.
3D model (JSmol)
|Molar mass||443.414 g/mol|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Interactive pathway mapEdit
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
- Maharaj, Geeta; Selinsky, Barry S; Appleman, James R; Perlman, Michael; London, Robert E; Blakley, Raymond L (2002). "Dissociation constants for dihydrofolic acid and dihydrobiopterin and implications for mechanistic models for dihydrofolate reductase". Biochemistry. 29 (19): 4554–4560. doi:10.1021/bi00471a008.
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