Denis Duboule

Denis Duboule (born February 17, 1955 in Geneva) is a Swiss-French biologist. He earned his PhD in Biology in 1984 and is currently Professor of Developmental Genetics and Genomics at the École polytechnique fédérale de Lausanne (EPFL) and at the Department of Genetics and Evolution of the University of Geneva. Since 2001, he is the Director of the Swiss National Research Center "Frontiers in Genetics" and since 2017, he is also a professor at the Collège de France. He has notably worked on Hox genes, a group of genes involved in the formation of the body plan and of the limbs.

Denis Duboule
Denis Duboule in 2010
Denis Duboule in 2010
Born (1955-02-17) February 17, 1955 (age 66)
CitizenshipSwiss and French
Known forWork on Hox genes
AwardsLouis-Jeantet Prize for Medicine (1998)[1]
Marcel Benoist Prize (2003)
Grand Prix Charles-Leopold Mayer (2004)
Fellow of the Royal Society[2]
Scientific career
FieldsDevelopment biology


Denis Duboule obtained a PhD from the University of Geneva in 1984. After questioning Karl Illmensee's claims of having cloned a mouse, Duboule departed to work as a post-doc and then a group leader at the University of Strasbourg, with Pierre Chambon. In 1988, he became a group leader at the European Molecular Biology Laboratory in Heidelberg, Germany.

In 1992, he obtained a tenure at the Geneva University. From 1997, he has headed the Department of Genetics and Evolution (formerly Zoology and Animal Biology) Since 2001, he has also chaired the NCCR Frontiers in Genetics and, since 2006, he is a full professor at the École polytechnique fédérale de Lausanne (EPFL).[3] In 2017, he was elected professor at the Collège de France, holding the international chair in genome evolution and development.[4]

He is a Fellow of the Royal Society.[2] and a member of the National Academy of Sciences[5] He is also an occasional columnist in the "Sciences and environment" section of the newspaper Le Temps.[6]

Scientific contributionsEdit

Denis Duboule has a longstanding interest in the function and regulation of Hox genes,[7] a family of genes responsible for the organization and evolution of animal body plans. These genes have been a paradigm to understand embryonic patterning, in developmental, evolutionary and pathological contexts. Denis Duboule's contributions are thus in the field of vertebrate developmental genetics with some interface with medical genetics and evolutionary biology. Since 1985, he reported several discoveries related to the biology of homeobox genes, in particular concerning the Hox gene family. A brief account can be found in the article "The Hox complex" [8]



  1. ^ a b Louis-Jeantet Prize
  2. ^ a b c Professor Denis Duboule ForMemRS
  3. ^ a b Denis Duboule,
  4. ^ Chaires internationales, on the web site on the Collège de France.
  5. ^ a b, National Academy of Sciences -. "Member Search". Retrieved 19 March 2018.
  6. ^ Denis Duboule, "Scanner. Un brin de causette", Le Temps, Wednesday 19 May 2010, p. 14.
  7. ^ Denis Duboule in Google Scholar
  8. ^ Duboule, D. (2009). "The Hox complex - an interview with Denis Duboule. Interviewed by Richardson, Michael K.". Int J Dev Biol. 53 (5–6): 717–23. doi:10.1387/ijdb.072558mr. PMID 19557678.
  9. ^ "Denis Duboule". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 29 January 2016. Retrieved 29 January 2016.

External linksEdit