He was a Roman Catholic, born 14 January 1810, the son of Mary Dewhurst and Edward Noble of Preston, Lancashire, a descendant of a Yorkshire Catholic family. Apprenticed to a Preston surgeon named Thomas Moore, Noble was in time admitted a member of the Royal College of Surgeons of England and a licentiate of Apothecaries Hall. In 1834 he began to practise in Manchester, becoming a specialist in mental illness.
Noble was President of the Manchester Phrenological Society from 1835 to 1838 but had turned away from the subject by the early 1840s, a time that coincided with his rise in social and professional status and also the general realisation that phrenology was unlikely ever to be accepted by the British Association for the Advancement of Science.
In 1842 he who wrote the anonymous article titled "True and False Phrenology" in the aftermath of an address of seismic proportions, given by William Collins Engledue in 1842, that significantly split the Phrenological Association and led to Noble's own resignation from it.
Noble dropped phrenological ideas completely in 1846 after criticism from William Benjamin Carpenter, who favoured the theory of brain physiology. That criticism came in a review of Noble's Brain and Its Psychology and his renunciation was formally recorded in his Elements of Psychological Medicine, published in 1853.
On 9 February 1847, Noble assisted his friend, Manchester surgeon James Braid, to (successfully) conduct a mastectomy, using inhalation ether as an anaesthetic agent. Braid was, perhaps, one of the first thirty surgeons in the U.K. ever to use inhalation ether as an anaesthetic.
Noble died at Manchester on 12 January 1885.
- An Essay of the Means, physical and moral, of estimating Human Character 1835
- Facts and Observations relative to the influence of manufactures upon health and life 1843
- Mesmerism true, mesmerism false: A critical examination of the facts, claims, and pretensions of animal magnetism 1846
- The Brain and its Physiology, a critical disquisition of the methods of determining relations subsisting between the structure and functions of the encephalon 1846
- Elements of Psychological Medicine: an Introduction to the practical study of Insanity 1853-1855
- Three Lectures on the Correlation of Psychology and Physiology 1854
- The Human Mind in its relations with the Brain and Nervous System 1858
- On certain popular fallacies concerning the production of epidemic diseases 1859
- On the fluctuations in the death-rate 1863
- Evanescent Protestantism and Nascent Atheism, the modern religious problem 1877
- On causes reducing the effects of sanitary reform 1878.
- Herbermann, Charles, ed. (1913). Catholic Encyclopedia. New York: Robert Appleton Company. .
- Cooter, Roger (1980). "Deploying "Pseudo-Science": Then and Now". In Hanen, Marsha P.; Osler, Margaret; Weyant, Robert (eds.). Science, Pseudo-science, and Society. Wilfrid Laurier Univ. Press. p. 256. ISBN 978-0-88920-100-2.
- True and False Phenology,The British and Foreign Medical Review, Vol.14, No.27, (July 1842), pp.65-80.
- Cooter, Roger (1984). The Cultural Meaning of Popular Science: Phrenology and the Organization of Consent in Nineteenth-Century Britain. Cambridge University Press. pp. 94-96, 292. ISBN 978-0-52122-743-8.
- Cooter, Roger (2015). "Phrenology and British Alienists". In Scull, Andrew (ed.). Madhouses, Mad-Doctors, and Madmen: The Social History of Psychiatry in the Victorian Era. University of Pennsylvania Press. pp. 85–86. ISBN 978-1-51280-682-3.
- Andrews, Jonathan. "Monro, Henry". Oxford Dictionary of National Biography (online ed.). Oxford University Press. doi:10.1093/ref:odnb/18974. (Subscription or UK public library membership required.)
- Braid practised/resided at 67 Piccadilly Manchester, and Noble practised/resided at 105 Piccadilly.
- Note that (i) the anaesthetic agent was inhaled, rather than ingested; and, (ii) in this case, the ether was administered by Braid's, son, James Braid, MD (1822–1882).
- See Yeates, L.B., James Braid: Surgeon, Gentleman Scientist, and Hypnotist, Ph.D. Dissertation, School of History and Philosophy of Science, Faculty of Arts & Social Sciences, University of New South Wales, January 2013, pp.365, 767, 809.
- Margaret M. Maison, The Victorian Vision (1961), p. 179; Archive.org.