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DNA2-like helicase is an enzyme that in humans is encoded by the DNA2 gene.[5][6][7] Dna2, a homolog of DNA2KL present in budding yeast, possesses both helicase and nuclease activity, with which it helps catalyze early steps in homologous recombination.[8]

DNA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDNA2, DNA2L, hDNA replication helicase/nuclease 2
External IDsMGI: 2443732 HomoloGene: 6124 GeneCards: DNA2
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for DNA2
Genomic location for DNA2
Band10q21.3Start68,414,064 bp[1]
End68,472,121 bp[1]
RNA expression pattern
PBB GE DNA2L 213647 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080449

NM_177372

RefSeq (protein)

NP_001073918

NP_796346

Location (UCSC)Chr 10: 68.41 – 68.47 MbChr 10: 62.95 – 62.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138346 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036875 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, Shibata T, Murakami Y, Hanaoka F (Mar 1997). "Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1". Genomics. 37 (3): 408–10. doi:10.1006/geno.1996.0581. PMID 8938459.
  6. ^ Masuda-Sasa T, Polaczek P, Campbell JL (Dec 2006). "Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation". J Biol Chem. 281 (50): 38555–64. doi:10.1074/jbc.M604925200. PMID 17032657.
  7. ^ "Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast)".
  8. ^ Mimitou, EP; Symington, LS (May 2009). "Nucleases and helicases take center stage in homologous recombination". Trends in Biochemical Sciences. 34 (5): 264–272. doi:10.1016/j.tibs.2009.01.010. PMID 19375328.

Further readingEdit