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Delta(4)-desaturase, sphingolipid 2 is a protein that in humans is encoded by the DEGS2 gene.[5]

DEGS2
Identifiers
AliasesDEGS2, C14orf66, DES2, FADS8, delta(4)-desaturase, sphingolipid 2, delta 4-desaturase, sphingolipid 2
External IDsOMIM: 610862 MGI: 1917309 HomoloGene: 23617 GeneCards: DEGS2
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for DEGS2
Genomic location for DEGS2
Band14q32.2Start100,143,957 bp[1]
End100,159,645 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_206918

NM_001171002
NM_027299

RefSeq (protein)

NP_996801

NP_001164473
NP_081575

Location (UCSC)Chr 14: 100.14 – 100.16 MbChr 12: 108.68 – 108.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FunctionEdit

This gene encodes a bifunctional enzyme that is involved in the biosynthesis of sphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase.

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168350 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021263 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Delta(4)-desaturase, sphingolipid 2".

Further readingEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.