D-glycero-beta-D-manno-heptose-7-phosphate kinase (EC 2.7.1.167, heptose 7-phosphate kinase, D-beta-D-heptose 7-phosphotransferase, D-beta-D-heptose-7-phosphate kinase, HldE1 heptokinase, glycero-manno-heptose 7-phosphate kinase, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, hldE (gene), rfaE (gene)) is an enzyme with systematic name ATP:D-glycero-beta-D-manno-heptose 7-phosphate 1-phosphotransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| D-glycero-beta-D-manno-heptose-7-phosphate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.167 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- D-glycero-beta-D-manno-heptose 7-phosphate + ATP D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.7.70).
References edit
- ^ McArthur F, Andersson CE, Loutet S, Mowbray SL, Valvano MA (August 2005). "Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis". Journal of Bacteriology. 187 (15): 5292–300. doi:10.1128/jb.187.15.5292-5300.2005. PMC 1196024. PMID 16030223.
- ^ Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (January 2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli". Journal of Bacteriology. 184 (2): 363–9. doi:10.1128/jb.184.2.363-369.2002. PMC 139585. PMID 11751812.
- ^ Valvano MA, Messner P, Kosma P (July 2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology. 148 (Pt 7): 1979–89. doi:10.1099/00221287-148-7-1979. PMID 12101286.
- ^ Jin UH, Chung TW, Lee YC, Ha SD, Kim CH (October 2001). "Molecular cloning and functional expression of the rfaE gene required for lipopolysaccharide biosynthesis in Salmonella typhimurium". Glycoconjugate Journal. 18 (10): 779–87. PMID 12441667.
- ^ Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D (February 2010). "Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)". Biochemistry. 49 (6): 1072–81. doi:10.1021/bi902018y. PMC 2844805. PMID 20050615.
External links edit
- D-glycero-beta-D-manno-heptose-7-phosphate+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
